Ana Boskovic, PhD
Speaker
Talk Title: tRNA fragments – transferring information between generations
Description:
The phenomenon of intergenerational epigenetic inheritance in mammals is gaining a lot of attention, as it postulates that parental exposures can influence offspring developmental phenotypes and propensity of disease risk in the next generation. Using our paternal Low Protein diet paradigm, we uncover an unexpected role for 5’tRF-GG – a sperm-borne, diet-modulated small RNA – in regulation of early embryonic transcription and chromatin organization. We uncover the first mechanistic details underpinning paternal contribution to offspring phenotypes and are currently dissecting the molecular details of how adult phenotypes emerge from transient gene expression changes immediately after fertilization.
Don't Forget Dad! - Paternal Influence on Disease Programming
Mini Symposia II
Friday, March 15, 1:45 p.m. - 3:45 p.m.