Janine LaSalle, PhD
Speaker
Talk Title: Sexual dimorphism and imprinting in circadian entrainment of metabolism and behavior
Description:
Circadian entrainment is the ability of mammals to adapt to a new time zone or lighting environment by altering expression of rhythmic genes. To explore the role of the imprinted noncoding gene Snord116 in orchestrating circadian entrainment, we entrained wild-type, Snord116 deletion, Snord116 overexpressing, and compensation mice to either 11:11 or 12:12 hours of light:dark for three weeks and examined metabolism, running wheel activity, and gene expression in the frontal cortex. Snord116 was required for the adaptive changes of entrainment on gene expression. Interestingly, females adapted to new light cycle by changing their metabolism to become less diurnal, while males adapted by decreasing their activity.
Circadian Rhythmicity and Lifelong Health
Mini Symposia II
Friday, March 15, 1:45 p.m. - 3:45 p.m.