Jose C. Jimenez-Chillarón, PhD
Speaker
Talk Title: Intergenerational inheritance of obesity and hepatic steatosis: The role of germline microRNAs
Description:
• Parental health strongly influences offspring disease risk.
• Specifically, paternal obesity increases the risk of obesity, and hepatic steatosis.
• Paternal inheritance of metabolic disease risk is largely attributed to nongenetic mechanisms. Namely, germline epigenetic mechanism.
• We have identified that small non-coding RNAs (miRNAs, TRFs) may mediate the risk of developing obesity-hepatic steatosis in a mouse model of obesity.
Don't Forget Dad! - Paternal Influence on Disease Programming
Mini Symposia II
Friday, March 15, 1:45 p.m. - 3:45 p.m.