Detailed Agenda

Your Grant in One Page Clinic

Registration

1:00 p.m. - 5:45 p.m.

Career Development Workshops

6:00 p.m. - 7:30 p.m.

Mentor in a Cloud Networking Event
*Members Only - Sign-up prior to event is required

Registration

LOBBY - VCC EAST LEVEL 1 

8:30 a.m. - 12:00 p.m.

Satellite Meetings

VARIOUS ROOMS

12:00 p.m. - 1:00 p.m.

Mid-Career Session
*Boxed lunches are available for purchase through the Advance Registration Deadline only.

EAST MEETING ROOM 11 & 12 - VCC EAST LEVEL 2

1:30 p.m. - 5:00 p.m.

Satellite Meetings

VARIOUS ROOMS

5:15 p.m. - 6:15 p.m.

New Investigator Forum

EAST MEETING ROOM 11 & 12 - VCC EAST LEVEL 2

6:30 p.m. - 8:00 p.m.

Welcome Reception

EAST BALLROOM AB -VCC EAST LEVEL 1

Registration

8:00 a.m. - 9:00 a.m.

8:00 a.m. - 8:10 a.m.

President's Welcome

EAST BALLROOM ABC -VCC EAST LEVEL 1

8:10 a.m. - 9:00 a.m.

March of Dimes Developmental Biology Prize Presentation and Lecture and Agnes Higgins Award Announcement

The March of Dimes and Richard B. Johnston, Jr., MD Prize in Developmental Biology honors an outstanding scientist who has profoundly advanced the science that underlies our understanding of pregnancy, parturition and prenatal development. The Prize is sponsored by the Society for Reproductive Investigation, whose mission to advance reproductive and women’s health care through outstanding basic, translational and clinical science and by training and mentoring future generations of investigators complements March of Dimes’ work to support healthy moms and strong babies. The recipients of the Prize are leaders in reproductive biology working on translational and actionable science that can develop into interventions or preventions that will improve the health of moms and babies everywhere.

EAST BALLROOM ABC -VCC EAST LEVEL 1

9:00 a.m. - 10:00 a.m.

President's New Investigator Plenary - 
Supported by the Past Presidents' Fund

EAST BALLROOM ABC -VCC EAST LEVEL 1

Moderators: 
Sandy T. Davidge, PhD, FCAHS
Stephen J. Lye, PhD

O-001: Premenstrual Dysphoric Disorder (PMDD) is Associated with Estradiol-dependent Aberrations in Cellular Ca2+ Homeostasis and the Endoplasmic Reticulum Stress Response
Howard Li, MD

O-002: Fetal Heart Rate Decelerations in Women with Sleep-Disordered Breathing
D'Angela S. Pitts, MD

O-003: Acute Treatment with Granulocyte-Colony Stimulating Factor at Advanced Reproductive Age Improves Ovarian Reserve
Natalie M. Hohos, PhD

O-004: Placental Central Carbon Metabolism Links Polyamines to Histone Acetylation
Giulia Avellino

10:00 a.m. - 10:30 a.m.

SRI President's Presenters Awards Presentation

EAST BALLROOM ABC -VCC EAST LEVEL 1

10:30 a.m. - 12:00 p.m.

Poster Session I

EAST EXHIBIT HALL B - VCC EAST LEVEL 1

12:00 p.m. - 1:30 p.m.

Lunch and Learn Symposium I 
*Boxed lunches are available for purchase through the Advance Registration Deadline only.

EAST MEETING ROOM 1 - VCC EAST LEVEL 2

Big Data and the Impact on Scientific Success
Moderators: 
Dorothy K. Sojka, PhD
Aleksandar K. Stanic, MD, PhD

Introduction to Big Data Analysis
Piraye Yurttas Beim, PhD

12:30 p.m. - 1:00 p.m.

Multi-Omics Approach in Uterine Fibroids Research
Benedikt Kessler, PhD

1:00 p.m. - 1:30 p.m.

Systems Biology Study to Puzzle out Preterm Birth with an Integrated-Omics Approach
Nanbert Zhong, MD, PhD 

12:00 p.m. - 1:30 p.m.

Lunch and Learn Symposium II 
*Boxed lunches are available for purchase through the Advance Registration Deadline only.

EAST MEETING ROOM 11&12 - VCC EAST LEVEL 2

NIH and Reproductive Medicine
Moderators: 
Irina Burd, MD, PhD​
Emre Seli, MD

NICHD Strategic Planning Update
Diana Bianchi, MD

12:25 p.m. - 12:50 p.m.

Strategies for Obtaining NIH Extramural Funding
Lisa Halvorson, MD

12:50 p.m. - 1:15 p.m.

Life as an Intramural NIH Researcher
Alan DeCherney, MD

1:15 p.m. - 1:30 p.m.

Introduction of NIH/NICHD Staff
Diana Bianchi, MD

1:35 p.m. - 3:35 p.m.

Concurrent Mini-Symposia I

VARIOUS ROOMS

Antenatal Steroid Therapy Optimisation. From Clinic to Bench and Back Again
Moderators: 
Matthew W. Kemp, PhD
Cynthia Gyamfi-Bannerman, MD, MSc

EAST MEETING ROOM 13 - VCC EAST LEVEL 2

When, What and How Often? Revisiting the Scientific Basis of Antenatal Steroid Therapy
Stephen G. Matthews, PhD

2:05 p.m. - 2:35 p.m.

Hunting for Goldilocks - Efforts Past and Present to get Antenatal Steroid Dosing Just Right
Matthew W. Kemp, PhD

2:35 p.m. - 3:05 p.m.

Optimisation of Antenatal Steroids for Low and Middle Income Countries
Alan H Jobe, MD, PhD

3:05 p.m. - 3:35 p.m.

Short & Long Term Benefits & Risks of Multiple Courses of Antenatal Corticosteroids
Kellie E. Murphy MD, MSc

Pregnancy – A Lost Opportunity to Screen
Moderators: 
Sandy T. Davidge, PhD, FCAHS
Laura A. Magee, MD, FRCPC, MSc, FACP, FRCOG

EAST MEETING ROOM 11 & 12 - VCC EAST LEVEL 2

1:35 p.m. - 2:05 p.m.

Placental Insufficiency and Impact on Fetal Development
Emily J. Su, MD

2:05 p.m. - 2:35 p.m.

Screening for Subclinical Cardiovascular Disease Following Pre-Eclampsia
Fergus McCarthy, MSc, PhD

2:35 p.m. - 3:05 p.m.

Pregnancy Complications and the Life Course – Implications for the Child
Lucilla Poston, PhD

3:05 p.m. - 3:35 p.m.

Patient-Reported Outcomes and the Feasibility of Tracking Long-Term Cardiovascular Disease Outcomes – The Preeclampsia Foundation Registry
Eleni Tsigas

Role of miRNA’s and Inflammation in the Pathology of Endometriosis
Moderators: 
Asgerally T. Fazleabas, PhD
Valerie A. Flores, MD

EAST MEETING ROOM 2 - VCC EAST LEVEL 2

1:35 p.m. - 2:05 p.m.

Insights into Contributions of Stem Cell and Inflammatory Pathways in the Pathophysiology of Endometriosis 
Caroline E. Gargett, PhD

2:05 p.m. - 2:35 p.m.

Macrophages in the Pathophysiology of Endometriosis: Mouse Models As Tools for Clinical Translation 
Erin Greaves, PhD

2:35 p.m. - 3:05 p.m.

miRNA’s in Endometriosis: Pathological Insights and Clinical Implications from a Baboon Model 
Asgerally T. Fazleabas, PhD

3:05 p.m. - 3:35 p.m.

miRNA’s in Endometriosis: Diagnostic Potential and Pathophysiology in Women with Disease
Hugh S. Taylor, MD

Reproductive Infectious Diseases: From Bench to Bedside to Tomorrow
Moderators: 
Lynn M. Yee, MD, MPH
David M. Aronoff, MD

EAST MEETING ROOM 3 - VCC EAST LEVEL 2

1:35 p.m. - 2:05 p.m.

Understanding the Management of Hepatitis B and C in Pregnant or Reproductive Age Women
Lynn M. Yee, MD, MPH

2:05 p.m. - 2:35 p.m.

Mechanisms of Group B Streptococcus as a Cause of Chorioamnionitis, Preterm Birth & Stillbirth
David M. Aronoff, MD

2:35 p.m. - 3:05 p.m.

Placental Malaria: The Inflammatory Response and Fetal Growth Restriction
Stephanie L. Gaw, MD, PhD

3:05 p.m. - 3:35 p.m.

STIs, the Vaginal Microbiome, and Reproductive Health: Recent Evidence and Clinical Applications
Lisa Haddad, MD, MS

Embryo Aneuploidy and Mosaicism: Implications for Reproduction and ART
Moderators:
Robert N. Taylor, MD, PhD
Mindy S. Christianson, MD

EAST MEETING ROOM 8 & 15 - VCC EAST LEVEL 2

1:35 p.m. - 2:05 p.m.

Understanding Aneuploidy
Pat Hunt, PhD

2:05 p.m. - 2:35 p.m.

Developmental Potential of Aneuploid Human Embryos Beyond Implantation
Magdalena Zernicka-Goetz, PhD

2:35 p.m. - 3:05 p.m.

Assessment of Aneuploidy and Mosacisim in Human Embryos: Promises and Pitfalls of Molecular Approaches and Study Designs
Richard T. Scott Jr., MD

3:05 p.m. - 3:35 p.m.

New Insights from Clinical NIPT Data Regarding Human Aneuploidy and Mosaicism
Diana W. Bianchi, MD

Update on Diagnostics and Therapeutics for Preterm Birth
Moderators: 
David M. Olson, PhD
Kelycia B. Leimert, PhD

EAST BALLROOM ABC - VCC EAST LEVEL 1

1:35 p.m. - 2:05 p.m.

The Need for, Barriers to, and Hope for New Preterm Birth Diagnostics and Therapeutics
David M. Olson, PhD

2:05 p.m. - 2:35 p.m.

New and Emerging Biomarker Prediction Tests for Preterm Birth
Laura Jelliffe-Pawlowski, PhD 

2:35 p.m. - 3:05 p.m.

Development of Novel Therapeutics to Counter Preterm Birth
Sylvain Chemtob, MD, PhD 

3:05 p.m. - 3:35 p.m.

Challenges in Developing New Treatment Options for Preterm Birth – From Industry’s Perspective
Yosuke Komatsu, MD, PhD, FJSOG, FJSUM

3:35 p.m. - 4:00 p.m.

Coffee Break

FOYER SOUTH

4:00 p.m. - 6:00 p.m.

Concurrent Oral Presentations I

VARIOUS ROOMS

Clinical and Translational Perinatology I
Moderators: 
Michael J. Fassett, MD
Maritza G. Gonzalez, MD

EAST MEETING ROOM 2 – VCC EAST LEVEL 2

O-005: Maternal Urinary Metabolites in the Latter Half of Pregnancy Predict Gestational Diabetes Mellitus
Aisling Murphy, Jeffrey Gornbein, Ophelia Lin, Brian Koos

O-006: Advanced Paternal Age Is Associated With an Increased Risk of Spontaneous Miscarriage: A Systematic Review and Meta-Analysis
Nadia A. du Fossé, Marie-Louise P. van der Hoorn, Jan M.M. van Lith, Saskia le Cessie, Lisa Elo Lashley

O-007: Placental MiRNAs Predicted to Target Insulin Signaling Pathways are Associated with Maternal Insulin Resistance in Late Pregnancy
Fernanda Alvarado, William Beyer, Tomoko Kaneko-Tarui, Tianjiao Chu, Yoel Sadovsky, Patrick Catalano, Perrie O’Tierney-Ginn

O-008: Postpartum Transient Elastography in Patients with Metabolic Disorders of Pregnancy
Farrah Naz Hussain, Lois Brustman, Emily Schneider, Emily Schmidt-Beautchat, Clara Rodriguez-Rivas, Melissa T. Chu Lam, Kristina M. Feldman, Tatyana Kushner

O-009: Adipose Tissue Extracellular Vesicles from Women with Gestational Diabetes Exhibit Tissue-specific Suppression of Insulin Signaling
Angela Rodriguez Boyd, Marcel Fourcaudot, Ralph DeFronzo, Luke Norton

O-010: A Novel Murine Model of Cytomegalovirus Infection in Pregnancy
Angela Shaddeau, Anna Chudnovets, Quan Na, Ayan Ghosh, Halli Miller, Jun Lei, Ravit Boger, Irina Burd

O-011: Anti-LPS Antibodies and Stillbirths
Yiping Han, Qing Meng, Zhezhen Jin, Robert Goldenberg, Robert Silver Emilie Vander Haar, Cynthia Gyamfi-Bannerman, Ron Wapner, Stillbirth Collaborative Research Network

O-012: Regulatory T Cell Adoptive Transfer Alters Macrophage Populations at the Maternal-Fetal Interface and Decreases Late Fetal Loss
Emma L. Lewis, Amy G. Brown, Paige M. Porrett, Michal A. Elovitz

Gynecology I
Moderators: 
TBC
Reshef Tal, MD, PhD

EAST BALLROOM ABC – VCC EAST LEVEL 1

O-013: Single Cell Transcriptomes From Uterine Fibroids and Fibroid-Free Myometrium Elucidate Myometrial Tumorigenesis
Wanxin Wang, Aymara Mas, Patricia Escorcia, Javier Monleon, Stephen Quake, Carlos Simon

O-014: Effect of Selective Progesterone Receptor Modulator (SPRM), Ulipristal Acetate (UPA) on Uterine and Fibroid Volume Measured by Unbiased Stereology and MRI
Hilary Critchley, Kaiming Yin, Lucy Whitaker, Suzanne McLenachan, Jane Walker, Graham McKillop, Neil Roberts

O-015: Nintedanib Alters Hippo Signaling in Uterine Fibroid Cells Leading to Decreased Levels of Connective Tissue Growth Factor and Cyclin D1, and Reduced Fibroid Cell Proliferation
Md Soriful Islam, Ha Vi S. Nguyen, Jacqueline Y. Maher, Joshua T. Brennan, James H. Segars

O-016: Association Between Anxiety/Depression, Uterine Fibroid Symptomology and Health Status Among Women Undergoing Interventional Treatments for Uterine Fibroids
K. Wallace, L. Feng, L. Thomas, S. Laughlin-Tommaso, E. A. Stewart, L. Wise, W. K. Nicholson, R. M. Anchan, G. L. Maxwell, V. L. Jacoby, G. R. Wegienka, P. Parry, B. L. Lytle, S. Venable, A. Shiflett, E. R. Myers, E. E. Marsh

O-017: Gene Expression Analysis of Foreign Body Response to Engineered Nano-Mesh with Endometrial Stem/Stromal Cells for Pelvic Organ Prolapse Repair
Shayanti Mukherjee, Saeedeh Darzi, Kallyanashis Paul, Fiona Cousins, Jerome A. Werkmeister, Caroline E. Gargett

O-018: Urogynecologic Mesh Complications: Low FGF Suggests Impaired Wound Healing
Amanda M. Artsen, Rui Liang, Steven D. Abramowitch, Pamela A. Moalli

O-019: Euploid Miscarriage is Associated with Lactobacillus spp. Deplete Vaginal Microbial Composition and Local Inflammation
Karen Grewal, Yun S. Lee, Ann Smith, Maya Al-Memar, Tom Bourne, David A. MacIntyre, Phillip Bennett

O-020: Pregnancy Outcomes Following Routine Early Provision of IUD After First Trimester Induced Abortion - 5-year Follow-up of a Randomized Controlled Trial
Elina Pohjoranta, Satu Suhonen, Maarit Mentula, Mika Gissler, Oskari M. Heikinheimo

Parturition I
Moderators: 
Sarah K. England, PhD
Hui Wang

EAST MEETING ROOM 8 & 15 - VCC EAST LEVEL 2

O-021: Evaluating Cervical Remodeling in Preterm and Term Birth Mouse Models with in vivo Raman Spectroscopy
Rekha Gautam, Jennifer Herington, Naoko Boatwright, Jackson Rogers, Wilson Adams, Jen Bateman, Christine O'Brien, Jeff Reese, Anita Mahadevan-Jansen

O-022: Polarized Light Imaging of the Pregnant Cervix
Jessica Ramella-Roman, Ilyas Saytashev, Sudipta Saha

O-023: In vivo Diffusion Tensor Imaging of the Cervix Early and Late in Normal Pregnancy
Wenxu Qi, Peinan Zhao, Hui Wang, Wenjie Wu, Zhexian Sun, Yong Wang

O-024: Essential Roles of Uterine Peristalsis by Cav1.2 in Reproduction and Adenomyosis in Mice
Mingzi Qu, Ping Lu, Christina Baer, Lawrence Lifshitz, Ronghua ZhuGe

O-025: NF-кB and AP-1 Transcription Factors Regulate Human 20 alpha HSD Transcription: Potential Pathways to Labour Induction
Lubna Nadeem, Rathesh Balendran, Oksana Shynlova, Sam Mesiano Stephen Lye

O-026: Dynamic MicroRNA 203 Expression Regulates Myometrial Smooth Muscle Cell Transient Receptor Vanilloid 4 Channel Expression During Pregnancy
Lihua Ying, Judith A. Ingles, Cristina M. Alvira, David N. Cornfield

O-027: Regulation of Mouse Uterine Contractility by Regulator of G-Protein Signalling 2
Daniela Urrego, Stephen L. Wood, Robert Newton, Donna M. Slater

O-028: Differential Regulation of SOX Family Transcription Factors in the Pregnant and Labouring Mouse Myometrium
Nawrah Khader, Virlana Shchuka, Anna Dorogin, Luis E. Abatti, Oksana Shynlova, Jennifer Mitchell

Placenta I
Moderators: 
Margareta D. Pisarska, MD
Yuliya Fakhr

EAST MEETING ROOM 11 & 12 - VCC EAST LEVEL 2

O-029: Cell-free DNA Methylation and Transcriptomic Signature Prediction of Pregnancies with Adverse Outcomes
Giorgia Del Vecchio, Qingjiao Li, Wenyuan Li, Shanthie Thamotharan, Anela Tosevska, Marco Morselli, Kyunghyun Sung, Carla Janzen, Xianghong Zhou, Matteo Pellegrini, Sherin U. Devaskar

O-030: Under-Expression of Placental Endocrine-Specific Igf2 Programmes Cardiovascular Disease in the Adult Male Offspring
W. Ching, Y. Niu, T. A. Garrud, H. Yong, E. R. Christoforou, J. Lopez-Tello, D. A. Giussani, A. N. Sferruzzi-Perri

O-031: Nanoparticle-Mediated Transgene Expression of Insulin-like Growth Factor in the Guinea Pig Placenta Reduces Angiogenic Factor Transcription but Enhances Glucose Transporter Expression
Rebecca L. Wilson, Kendal Stephens, Kristin Lampe, Helen Jones

O-032: Regulatory T Cells Determine Uterine Natural Killer Cell Abundance and Decidual Vascular Remodeling in Early Pregnancy in Mice
Alison S. Care, Holly M. Groome, Shanna L. Hosking, Claire T. Roberts, Sandra T. Davidge, Sarah A. Robertson

O-033: Novel Placental Cell Defense Against Lipotoxicity-induced Ferroptotic Death
Ofer Beharier, Julie Goff, Kazuhiro Kajiwara, Jennifer Guererro-Santoro, Tianjiao Chu, Vladimir A. Tyurin, Yulia Y. Tyurina, Samuel Parry, W. Tony Parks, Valerian E. Kagan, Yoel Sadovsky

O-034: Role of Toll-Like Receptor 8 (TLR8) in the Inflammatory Response to Virus in Hofbauer Cells (HBCs)
Victoria Lindstrom Chase, Zhonghua Tang, Gil G. Mor, Vikki M. Abrahams, Seth Guller

O-035: Less is More! Commensal Microbiome Supports Macrophage-Trophoblast-Interaction
Rebekka Einenkel, Damián Muzzio, Jens Ehrhardt, Martha Heusler, Meike Hofer, Kristin Hartmann, Theresa Meiner, Marek Zygmunt

O-036: Derivation of Human Trophoblast Stem Cells from Pluripotent Stem Cells to Model Early Placental Development
Francesca Soncin, Tony Buy, Mariko Horii, Omar A. Farah, Mana M. Parast

Maternal Biology and Health
Moderators: 
Egle Bytautiene Prewit, MD, PhD
TBC

EAST MEETING ROOM 13 – VCC EAST LEVEL 2

O-037: The Influence of Artificial Sweetener During Pregnancy on Long Term Maternal Health
Pania E. Bridge-Comer, Ana Paula Machado Spara, Jasmine F. Plows, Jacon Morton-Jones, Mark H. Vickers, Clare M. Reynolds

O-038: Mechanisms of Action of Intervention in the PHOENIX Trial: In Women with Preterm Preeclampsia Does Planned Delivery Improve Postpartum Maternal Cardiac Function Through Attenuation of Myocardial Ischaemia at Time of Disease (PHOEBE Study)?
Fergus McCarthy, Jamie O’Driscoll, Paul Seed, Mike Marber, Anna Placzek, Lucilla Poston, Andrew Shennan, Basky Thilaganathan, Paul Leeson, Lucy Chappell

O-039: Maternal Obesity During Pregnancy Induces Oxidative Stress and Mitochondria Functional Alterations in the Maternal Liver
Luis Grilo, João D. Martins, Chiara H. Cavallaro, Inês Cardoso, Inês Baldeiras, Teresa Cunha-Oliveira, Stephen Ford, Peter W. Nathanielsz, Paulo J. Oliveira, Susana P. Pereira

O-040: 10 Years Prediction Model for Chronic Hypertension AfterPreeclampsia in Initially Normotensive Women
Mieke Hooijschuur, Marc E.A. Spaanderman, Jori M.J. Meijers, Eva Mulder, Chahinda Ghossein-Doha

O-041: Postpartum Hemorrhage After Vaginal Delivery is Associated with a Decrease in Immediate Breastfeeding Success
Lilly Y. Liu, Patricia Rekawek, MacKenzie Naert, Julie Cadet, Johanna Monro, Joanne Stone

O-042: Changes in Maternal Gut Microbiome Diversity and Composition Associated with Infant Feeding Behaviors
Adetola Louis-Jacques, Jean Lim, Anujit Sarkar, Tina Ho, Ronald R.Magness, Maureen Groer

O-043: Prenatal Maternal Stress Induces Preterm Birth and Impacts Neonatal Adaptive Immunity
Valeria Garcia-Flores, Roberto Romero, Jose Galaz, Chaur-Dong Hsu, David Olson, Gerlinde A. S. Metz, Nardhy Gomez-Lopez

O-044: Association of Pre-pregnancy Subclinical Insulin Resistance With Cardiac Dysfunction in Healthy Nulliparous Women
Rachel B.C. Psoinos, Erin A. Morris, Carole A. McBride, Ira M. Bernstein

Reproductive Biology I
Moderators: 
Joshua Johnson, PhD
Qiwei Yang, PhD

EAST MEETING ROOM 3 – VCC EAST LEVEL 2

O-045: Towards Three-Dimensional Imaging of the Murine Vagina
Kristin S. Miller, Diego Gatica, Bihe Hu, Elvis K. Danso, Katherine Elfer, J. Quincy Brown

O-046: Proteomic Analysis of Secretions from a Novel Endocervical Cell Culture Using Conditionally Reprogrammed Cells
Leo Han, Walker Andrews, Karsten Wong, Ashok Reddy, Phillip Wilmarth, Jeffrey T. Jensen

O-047: Differentiation of Mouse iPSCs into Functional Oocytes
Raymond M. Anchan, Nicholas W. Ng, Kha U. Dam, Ankrish Milne, Emily R. Disler, Nicole Dunn, Kevin M. Elias, Elizabeth Ginsburg

O-048: Mitochondrial Stress Response Gene Clpp is Not Required for Granulosa Cell Function
Ecem Esencan, Gizem A. Imamoglu, Mauro Cozzolino, Emre Seli

O-049: Exposure to Synthetic Glucocorticoids Modifies the Sperm MicroRNA Profile: Implications for Intergenerational Transmission
Christopher Casciaro, Hirotaka Hamada, Alisa Kostaki, Stephen Matthews

O-050: Recombinant AMH (rAMH) for Stalling in vitro Granulosa Cell Replication
Laura Detti, Irene Peregrin-Alvarez, Mary E. Christiansen, Pouran Malekzadeh, Jennifer Sledge, Ghassan M. Saed

O-051: Loss of Ovarian Expression of the Noncoding RNA H19 Promotes Susceptibility to Doxorubicin-induced DNA Damage
Jing Wang, Joshua Johnson, Amanda N. Kallen

O-052: Metabolomics Study of Mouse Blastocysts Cultured in a Microfluidic Device to Assess Development in Uterine Cell-Conditioned Media
Vanessa Mancini, Paul J. McKeegan, Stacy D. Sherrod, Alexandra C. Rutledge, Simona G. Codreanu, Helen M. Picton,Virginia Pensabene

6:15 p.m. - 7:45 p.m.

Connection Corners 

EAST MEETING ROOM 1 - VCC EAST LEVEL 2 

Registration

LOBBY - VCC EAST LEVEL 1

7:00 a.m. - 8:00 a.m.

SRI Business Meeting
*Breakfast will be served and ALL SRI Members are invited to attend

EAST MEETING ROOM 1 - VCC EAST LEVEL 2

8:00 a.m. - 8:30 a.m.

Grant Program Recipient Presentations

EAST BALLROOM BC - VCC EAST LEVEL 1

8:00 a..m - 8:15 a.m.

Investigation of Genome Wide DNA Methylation Changes in Mouse Embryos Associated with Superovulation
Bo Yu, MD
2017 – 2018 SRI Early Career Grant Recipient

8:15 a.m. - 8:30 a.m.

Unraveling the Consequences of Elevated Advanced Glycation End Product Levels on Female Fertility Jemma Evans, PhD
2017 – 2018 SRI Bridge Grant Recipient

8:30 a.m. - 9:30 a.m.

President's Distinguished Lecture I

EAST BALLROOM BC - VCC EAST LEVEL 1

Viral Noncoding RNAs: Approaching Answers
Joan A. Steitz, PhD 
Department of Molecular Biophysics and Biochemistry,
Yale University School of Medicine, New Haven, CT, USA

9:30 a.m. - 11:00 a.m.

Poster Session II

EAST EXHIBIT HALL B - VCC EAST LEVEL 1

11:00 a.m. - 12:30 p.m.

Concurrent Oral Presentations II

VARIOUS ROOMS

Developmental Programming I
Moderators: 
Lucilla Poston, PhD
Kathleen A. Pennington, PhD

EAST MEETING ROOM 13 – VCC EAST LEVEL 2

O-053: Sex-specific Alterations in the Early Embryonic Mouse Epigenome
Kathleen O'Neill, Sarah Johnston, Kim Taehyong, Xiang Zhang, Rebecca A. Simmons

O-054: A Life Course Approach to the Relationship Between Fetal Growth and HPA-Axis Function
Wrivu M. Martin, Carol A Wang, Stephen J. Lye, Rebecca M. Reynolds, Stephen G. Matthews, Carly E. McLaughlin, Roger Smith, Craig E. Pennell

O-055: Sex-Specific Effects of a Placenta-Targeted Treatment with nMitoQ on the Mechanisms of Cardiac Dysfunction in Adult Offspring Exposed to Hypoxia in utero
Nataliia Hula, Jennie Vu, Anita Quon, Raven Kirschenman, Christy-Lynn M. Cooke, Thomas J. Phillips, C. Patrick Case, Floor Spaans, Sandra T. Davidge

O-056: Perinatal Protein Deficiency and Postnatal Catch-up Growth Leads to Hepatic Mitochondrial Dysfunction in Adult IUGR Offspring
Shelby L. Oke, Gurjeev Sohi, Daniel B. Hardy

O-057: Iron Restriction During Pregnancy Causes Dysfunction and Morphological Changes in the Hearts of Neonatal Offspring
Ronan Noble, Jason Li, Andrew Woodman, Richard Mah, Ferrante Gragasin, Luke Eckersley, Stephane Bourque

O-058: Epigenetic Effects of N-acetylcysteine on H2S-Mediated Protection Against Fetal Origins of Vascular Disease
A. A. Paz, T. A. Garrud, E. Peñaloza, F. Vega-Tapia, S. G. Ford, Y. Niu, B. J. Krause, D. A. Giussani

Fetus I
Moderators: 
Janna L. Morrison, PhD
Stephen A. Contag, MD

EAST MEETING ROOM 3 – VCC EAST LEVEL 2

O-059: PiggyBac Transposase Mediated Inducible Trophoblast-specific Knockdown of Mechanistic Target of Rapamycin (mTOR) in Mice Decreases Placental Nutrient Transport and Inhibits Fetal growth
F. J. Rosario, J. Urschitz, T. L. Powell, T. Jansson

O-060: Effects of Nanoparticle-encapsulated MitoQ (nMitoQ) Delivery to the Placenta on Fetal Cardiomyocyte Development in a Rat Model of Prenatal Hypoxia
Esha Ganguly, Raven Kirschenman, Floortje Spaans, Thomas Phillips, Christy-Lynn Cooke, Patrick Case, Sandra T. Davidge

O-061: Exploring Genetic Variation in Normal and Diseased Human Placentas
Nathan R. Blue, Amelia Wallace, Aaron Quinlan, Robert M. Silver

O-062: An Aberrant Endothelial Cell Response to Flow: Mechanistic Implications for Congenital Heart Defects in the Feto-placental Unit
Yalda Afshar, Anhyo Jeong, William M. Jones, Luisa Iruela-Arispe

O-063: Low Dose Insulin Infusion in IUGR Fetal Sheep Stimulates Skeletal Myoblast Proliferation but Not Fiber Number
Eileen I. Chang, Byron Hetrick, Stephanie R. Wesolowski, Paul J. Rozance, Carrie E. McCurdy, Laura D. Brown

O-064: Decreased Mitochondrial Complex I Activity in Skeletal Muscle of Growth Restricted Ovine Fetuses with Placental Insufficiency
Alexander Pendleton, Melissa A. Davis, Amy C. Kelly, Leticia E. Camacho, Miranda J. Anderson, Paul R. Langlais, Sean W. Limesand

Preeclampsia I
Moderators: 
Thomas F. McElrath, MD, PhD
Anna Palatnik, MD

EAST MEETING ROOM 11 & 12 – VCC EAST LEVEL 2

O-065: Proinflammatory and Anti-inflammatory Cytokine Responses by Decidua T Cells in Preeclampsia
Ai-ris Yonekura Collier, Dan H. Barouch

O-066: Sulforaphane Improves Vascular Reactivity in Arteries After Preeclamptic-like Injury
Annie Georgina Cox, Kirsten R. Palmer, Euan M. Wallace

O-067: Progesterone Induced Blocking Factor Attenuates Hypertension, Placental and Endothelial Cell Mitochondrial Dysfunction and Reactive Oxygen Species in Response to sFlt-1 During Pregnancy
Lorena M. Amaral, Evangeline Deer, Kyleigh Comley, Denise C. Cornelius, Jalisa Jones, Tarek Ibrahim, Ramana Vaka, Michael Franks, Babbette LaMarca

O-068: Challenging the Definition of Hypertension in Pregnancy - A Retrospective Cohort Study
Maya Reddy, Daniel L. Rolnik, Katrina Harris,Wentao Li, Ben W. Mol, Fabricio da Silva Costa, Euan Wallace, Kirsten Palmer

O-069: Hypoxic Pregnancy Recapitulates In Vivo, Mitochondrial and Molecular Markers of Preeclampsia in the Mother, Placenta and Offspring
W. Tong, K. L. Brain, B. J. Allison, K. J. Botting, Y. Niu, S. G. Ford, P. F.B. Wooding, Q. Lyu, L. Zhang, K. A. O'Brien, A. P. Sowton, T. Cindrova-Davies, H. W. Yung, G. J. Burton, A. J. Murray, D. A. Giussani

O-070: Surgically Increasing Uteroplacental Impedance Results in Attenuated Uterine Vascular Remodeling and Preeclampsia-Related Placental Secretomics During Pregnancy
Nga Ling Ko, Narmin Mukhtarova, Catrina Hood, Ying Wai Lam, George Osol

Gynecology II
Moderators: 
Lisa M. Halvorson, MD
Elliott G. Richards, MD

EAST BALLROOM BC – VCC EAST LEVEL 1

O-071: Endometriosis Lesion-specific cxcr4 Knockdown Increases Estrous-cycle Dependent Intraepithelial Lymphocyte Infiltration in the Mouse, Compromising Lesion Integrity
Ai-ris Yonekura Collier, Dan H. Barouch

O-072: Targeting and Treatment of Endometriosis with Nanoparticles
Oleh Taratula, Olena Taratula, Abraham Moses, Fangzhou Luoi, Ov D. Slayden

O-073: Large-scale Genome-wide Association Meta-analysis of Endometriosis Reveals 44 Loci in 61K Cases and 711K Controls and Genetically-associated Comorbidity with Other Pain Conditions
Nilufer Rahmioglu, International Endometriosis Genomics Consortium

O-074: Microvascular Endothelium-Dependent Vasodilation is Impaired in Women with Endometriosis and Improved with Acute Atorvastatin Treatment
Anna E. Stanhewicz, Corinna F. Serviente, Gabrielle Dillon, Nina S. Stachenfeld, Hugh S. Taylor, Lacy M. Alexander

O-075: Identification ofFOXC1as a Key Transcriptional Regulator in Induced Endometriosis Lesions
Gregory W. Burns, Niraj R. Joshi, Kevin M. Elias, Asgerally T. Fazleabas

O-076: Spontaneous Ovarian Endometriosis in Mice with Deletion of Arid1a and Gain of Kras^G12D
Jillian R.H. Wendel, Xiyin Wang, Rakshin Kharwadkar, Xiaoyu Lu, Robert Emerson, Mark H. Kaplan, Chi Zhang, Shannon M. Hawkins

Parturition II
Moderators: 
John R.G. Challis, PhD, FRCOG, FRSC
Mancy Tong, PhD

EAST MEETING ROOM 8 & 15 – VCC EAST LEVEL 2

O-077: Lung Maturation in Extremely Preterm Fetal Lambs Maintained on an Artificial Placenta is Driven by Glucocorticoid Signalling, Not Inflammation
Erin Lesley Fee, Matthew Warren Kemp, Masatoshi Saito, Haruo Usuda

O-078: A Novel Allosteric Modulator of IL-6R Successfully Prevents Deleterious Effects of Inflammation in a LPS Model of Preterm Birth
Elizabeth Prairie, Sarah-Eve Loiselle, Frédérique Vermette-Lacroix, Xin Hou, Estefania Marin Sierra, Christiane Quiniou, Sarah Robertson, David Olson, Sylvain Chemtob

O-079: Enhanced Decidual FKBP51 Expression Promotes Idiopathic Preterm Birth by Inducing Functional Progesterone Withdrawal
Nihan Semerci ,Asli Ozmen, Ozlem Guzeloglu-Kayisli, Xiaofang Guo, Irina Buhimschi, Catalin Buhimschi, Frederick Schatz, Umit Kayisli, Charles Lockwood

O-080: Selective Progesterone Receptor Modulator Delays Term Labor and Prevents Preterm Labor in Mice
Oksana Shynlova, Lubna Nadeem, Anna Dorogin, Sam Mesiano, Stephen Lye

O-081: Multi-Omic, Longitudinal Profile of Third-Trimester Pregnancies Identifies a Molecular Switch That Predicts the Onset of Labor
Ina Stelzer, Mohammad Sajjad Ghaemi, Xiaoyuan Han, Kazuo Ando, Laura Peterson, Kevin Contrepois, Edward Ganio, Amy Tsai, Eileen Tsai, Kristen Rumer, Natalie Stanley, Ramin Fallazadeh, Martin Becker, Anthony Culos, Dyani Gaudilliere, Ronald Wong, Virginia Winn, Gary Shaw, David Stevenson, Michael Snyder, Martin Angst, Nima Aghaeepour, Brice Gaudilliere

O-082: Association Between Daily Melatonin and Cortisol Rhythms and Risk of Preterm Birth
Ronald T. McCarthy, Peinan Zhao, Anjana Delhi, Emily S. Jungheim, Justin C. Fay, Erik D. Herzog Sarah K. England

Reproductive Endocrinology and Infertility I
Moderators: 
Gaurang S. Daftary, MD
Mary Ellen Pavone, MD, MS

EAST MEETING ROOM 2 – VCC EAST LEVEL 2

O-083: An In Vivo Model of Human FSH Dysregulation in Obesity: Obese Women Exhibit Lower Serum FSH Levels in Response to Intravenous Recombinant FSH After GnRH Suppression
Katherine Kuhn, Thanh-Ha Luu, Andrew Bradford, Luke Wittenberg, Nne-Omoji Nwobodo, Alex Polotsky

O-084: A Multi-Center, Prospective, Blinded, Non-Selection Study Evaluating the Predictive Value (PV) of an Aneuploid Preimplantation Genetic Testing for Aneuploidy (PGT-A) Diagnosis and Impact of Biopsy
Ashley W. Tiegs, Xin Tao, Yiping Zhan, Chaim Jalas, Christine Whitehead, Emre Seli, George Patounakis, Jacqueline Gutmann, Arthur Castelbaum, Richard T. Scott

O-085: Identification of Novel PRDM9 DNA Binding Alleles in an Azoospermia Cohort
M. Blake Evans, Sherry Ralls, Mohamed Mahgoub, Micah J Hill, Alan H. DeCherney, Todd Macfarlan

O-086: A Superovulatory Uterine Environment Impacts Embryo Implantation, Results in Placental ER Stress and Reduces Fetal Growth of Both Fresh and Vitrified Embryos
Cassandra Roeca, Elena Silva, Kenneth Barentsen, Theresa Powell, Thomas Jansson

O-087: Anti Mullerian Hormone is Low in Women with Sickle Cell Disease Who Participated in the Multi-Center Study of Hydroxyurea
Lydia Pecker, Hyunwook Koh, Ni Zhao, Sophie Lanzkron, Mindy Christianson

O-088: Different Origins of Sperm and the Impact on Prenatal and Placental Growth Trajectories: The Rotterdam Periconception Cohort
Jeffrey Hoek, Willem Boellaard, Eva S. van Marion, Sten P. Willemsen, Régine P.M. Steegers-Theunissen, Sam Schoenmakers

12:35 p.m. - 2:05 p.m. 

Diversity, Equity and Inclusion Forum
*Boxed lunches will be provided at no cost for this session. The capacity for this session is 100 attendees and will registration for this session will close once full or on the Advance Registration Deadline.

EAST MEETING ROOM 1 – VCC EAST LEVEL 2

Moderator: 
Ayman Al-Hendy, MD, PhD

People Like You Can’t Do That
Genevieve S. Neal-Perry, MD, PhD, Chief, Reproductive Endocrinology and Infertility
University of Washington, Seattle, WA, USA

12:35 p.m. - 2:05 p.m.

Lunch and Learn Symposium III 
*Boxed lunches are available for purchase through the Advance Registration Deadline only.

Don't Get Lost in Translation: Importance of In Vivo and In Vitro Model Validation
Moderators: 
Irene Cervello, PhD
Erica E. Marsh, MD, MSCI, FACOG

EAST MEETING ROOM 11&12 – VCC EAST LEVEL 2

Back-Translation of Clinical Endpoints and Model Validation in Preclinical Research (fibroids examples)
Thomas M. Zollner, MD

1:20 p.m. - 2:05 p.m.

Modeling Artificial Ovary 
Monica M. Laronda, PhD

2:10 p.m. - 4:10 p.m.

Concurrent Mini-Symposia II

VARIOUS ROOMS

Controversies: Yes or No for Placental Microbiome
*Interactive Session
Moderator: 
Phillip R. Bennett, MD, PhD, FMedSci

EAST BALLROOM BC - VCC EAST LEVEL1

Panelist 1:
Kjersti Aagaard, MD, PhD

2:40 p.m. - 3:10 p.m.

Panelist 2: 
Frederic Bushman, PhD

3:10 p.m. - 3:40 p.m.

Panelist 3:  
Indira U. Mysorekar, PhD

3:40 p.m. - 4:10 p.m.

Panelist 4:
Michal A. Elovitz, MD

Reproduction Meets Imaging
Moderators:
Hari Eswaran, PhD
Jessica Ramella-Roman, PhD

EAST MEETING ROOM 13 - VCC EAST LEVEL 2

2:10 p.m. - 2:40 p.m.

In Vivo Imaging of Reproductive Dynamics in the Mouse Oviduct
Shang Wang, PhD

2:40 p.m. - 3:10 p.m.

Active Fluctuations Modulate Nuclear Dynamics in Oocytes
Marie-Helene Verlhac, PhD

3:10 p.m. - 3:40 p.m.

Quantitative Ultrasound of the Cervix in Pregnancy: Today & Tomorrow
Helen Feltovich, MD

3:40 p.m. - 4:10 p.m.

Preventing Postpartum Depression: An Intergenerational fMRI Clinical Trial
Kristen Mackiewicz Seghete, PhD

SRI – SSR Joint Session: Immune Cell Regulation of Implantation/Pregnancy
Moderators: 
Bo R. Rueda, PhD
Vikki M. Abrahams, PhD

EAST MEETING ROOM 8 & 15 - VCC EAST LEVEL 2

2:10 p.m. - 2:40 p.m.

Neutrophils at the Maternal-Fetal Interface: Friend or Foe?
Vikki M. Abrahams, PhD

2:40 p.m. - 3:10 p.m.

The Stage Is Set Before the Play Commences – Maternal Immunological Detection of the Conceptus
Troy Ott, PhD

3:10 p.m. - 3:40 p.m.

Maternal Immunity and Tolerance During Pregnancy
Margaret G. Petroff, PhD

3:40 p.m. - 4:10 p.m.

Fetal-Maternal Disagreement: Immune Responses in Placental Villitis
Elizabeth Ann Enninga, PhD

SRI – PRS Joint Session: Interaction at the Maternal-Fetal Interface and Origins of Child Health and Disease
Moderators: 
Maide Ozen, MD
Yoel Sadovsky, MD

EAST MEETING ROOM 11 & 12 - VCC EAST LEVEL 2

2:10 p.m. - 2:40 p.m.

Implications of Immunoperinatology Research on Neonatal and Lifetime Health
Maide Ozen, MD

2:40 p.m. - 3:10 p.m.

Multidisciplinary, Multiplatform Approaches to Unravel the Mechanisms of Adverse Pregnancy Outcomes
Nima Aghaeepour, PhD

3:10 p.m. - 3:40 p.m.

Next Frontiers in Vesicle-Based Placental-Maternal-Fetal Communication  
Yoel Sadovsky, MD

3:40 p.m. - 4:10 p.m.

Gaps in Knowledge in Understanding the Immunobiology and Immunopathology of Pregnancy and Future Directions
Ana Claudia Zenclussen, PhD

Drivers and Therapeutic Targets for Gynecologic Cancers Associated with Benign Gynecologic Conditions
Moderators:
Dineo Khabele, MD, FACOG, FACS
Gloria Huang, MD

EAST MEETING ROOM 3 - VCC EAST LEVEL 2

2:10 p.m. - 2:40 p.m.

ARID1A as a Driver and Target for Therapy for Endometriosis-Associated Ovarian Cancer (Implications for Immunotherapy)
Rugang Zhang, PhD

2:40 p.m. - 3:10 p.m.

Toxicant Exposure, Endocrine Disruptors and Adenomyosis (Environmental Influence)
Kaylon L. Bruner-Tran, PhD

3:10 p.m. - 3:40 p.m.

The Insulin/Insulin Growth Factor and Sex Hormone Axes in the Normal Endometrium and in Tumor Microenvironment of Endometrial Cancer (Environmental Influence of Obesity and Implications for Immunotherapy)
Gloria Huang, MD

3:40 p.m. - 4:10 p.m.

Mouse Models of Endometriosis-Associated Gynecologic Cancers
Warren B. Nothnick, PhD

Stem Cell Therapy of Reproductive Disorders
Moderators: 
Ayman Al-Hendy, MD, PhD
Sonia Herraiz, PhD

EAST MEETING ROOM 2 - VCC EAST LEVEL 2

2:10 p.m. - 2:40 p.m.

Opportunities and Challenges in Regenerative Therapies
Sonia Herraiz, PhD

2:40 p.m. - 3:10 p.m.

Stem Cell and Gene Therapy of Ovarian Infertility: from Bench to Rodents to Women, and Back
Ayman Al-Hendy, MD, PhD

3:10 p.m. - 3:40 p.m.

Cell Therapy of Asherman Syndrome and Endometrial Atrophy
Carlos Simon, MD, PhD

3:40 p.m. - 4:10 p.m.

Cell Therapy of Male Infertility
Kyle Orwig, PhD

4:10 p.m. - 4:25 p.m. 

Coffee Break

FOYER SOUTH

4:30 p.m. - 6:00 p.m.

Concurrent Oral Presentations III

VARIOUS ROOMS

Epidemiology and Global Health
Moderators: 
TBC
TBC

EAST MEETING ROOM 1 – VCC EAST LEVEL 2

O-089: Likelihood of Women Achieving More Than One Live Birth After Various Types of Cancers
Deepika Garg, Huong Dieu Meeks, Erica Johnstone, Alexander Pastuszak, Sarah Berga, Ken Smith, Jim Hotaling, Joseph M. Letourneau

O-090: Women with History of Pregnancy Complications Have Higher Risk of Midlife Stroke: The PATH Study
Eliza C. Miller, Rindcy E. Davis, Natalie A. Bello, Alexander M. Friedman, Amelia K. Boehme, Sarah E. Tom

O-091: Analysis of Fetal Birth Weight Percentiles at Birth Improves Our Understanding of How the Maternal Postpartum Phenotype is Linked to Poor Pregnancy Outcome
Calvin J. Hobel, Christine M. Guardino, Max Mansolf, Richard Liang, James Mirocha, Christine Dunkel Schetter

O-092: Losing Specificity. The Unintended Harm of Improved Detection of Fetal Growth Restriction
Roshan Selvaratnam, Mary-Ann Daveym, Shirin Anil, Susan J. McDonald, Tanya Farrell, Euan M. Wallace

O-093: Racial Disparities in Infant Mortality Following Singleton Pregnancies in the US
Adwoa Baffoe-Bonnie, Jasmine Johnson, Celeste Green, Tracy Manuck

O-094: Confidential Review of Maternal Deaths in the Community Level Interventions for Pre-Eclampsia Pakistan Trial
Annet M. Aukes, Kristina Arion, Rahat N. Qureshi Sumedha Sharma,Tang Lee, Beth A. Payne, Jing Li, Marianne Vidler, Jefrey Bone, Zulfiqar A. Bhutta, Peter von Dadelszen, Laura A. Magee, CLIP Pakistan Working Group

Development Programming II
Moderators: 
Jorge P. Figueroa, MD, PhD
Chiara Mando, PhD

EAST MEETING ROOM 2 – VCC EAST LEVEL 2

O-095: Maternal Adiposity Alters Hippocampal Epigenomic and Transcriptomic Profiles in the Fetal Baboon
Ashley A. Martin, Sarah O. Ocanas, Hunter Porter, Martin-Paul Agbaga,Willard M. Freeman, Dean A. Myers

O-096: Sexual Dimorphic Mechanisms of Programming of Adipose Tissue (AT) Expansion by Maternal Obesity (MO) in the Rat
Carlos A. Ibáñez-Chávez, Gabriela Lira-León, Luis A. Reyes-Castro, Consuelo Lomas Soria, Alejandra Hernández-Rojas, Eyerahí Bravo-Flores, Mario Solís-Paredes, Guadalupe Estrada-Gutiérrez, Fernando Larrea, Peter W. Nathanielsz, Elena Zambrano González

O-097: Pronuclear Transfer Reveals Oocyte Nucleus is Sufficient to Transmit Cardiac Mitochondrial Abnormalities in Offspring of Obese Dams
Jeremie L. Ferey, Meghan Ruebel, Keith Latham, Kelle Moley, Abhinav Diwan

O-098: Maternal Obesity (MO) in Sheep Elevates Fetal Left Ventricular (LV) Tissue Cortisol Concentration and the Components of the 11βhydroxysteroid Dehydrogenase (11βHSD1) System at Term
Qiurong Wang, Steven P. Ford, Wei Guo, Peter W. Nathanielsz

O-099: Females Are Not Just ‘Protected’ Males: Sex-Specific Vulnerabilities In Placenta and Brain After Prenatal Immune Disruption
Amy E. Braun, Pamela A. Carpentier, Brooke A. Babineau, Aditi R. Narayan, Michelle L. Kielhold, Hyang Mi Moon, Jennifer Su,Vidya Saravanapandian, Theo D. Palmer

O-100: Maternal Obesity Diminishes Inhibitory Interneuron Function in Rat Hippocampus
Helena C. Parkington, Ammar Abdulwahid, Harold A. Coleman

Reproductive Biology II
Moderators: 
Yoel Sadovsky, MD
Irene Cervello, PhD

EAST MEETING ROOM 3 – VCC EAST LEVEL 2

O-101: The Role of Sirt1 and Progesterone Resistance in Normal and Abnormal Uterine Physiology: A Novel Hypothesis
Bruce A. Lessey, Abigail Gifford, Tae Hoon Kim, Asgerally T. Fasleabas, Steven L. Young, Jae-Wook Jeong

O-102: Extracellular Vesicles Secreted by Uterine Decidual Cells Carry Critical Information for Establishment of Pregnancy
Indrani C. Bagchi, Qiuyan Ma, Arpita Bhurke, Kannan Athilakshmi, Jie Yu, Robert N. Taylor, Milan K, Bagchi

O-103: Loss of MIG-6 Results in Endometrial Progesterone Resistance and Endometriosis-related Infertility Through ERBB2 Overexpression
Tae Hoon Kim, Jung-Yoon Yoo, Jung-Ho Shin, Ulrich Müller, Asgerally T. Fazleabas1, Steven L. Young, Bruce A. Lessey, Ho-Geun Yoon, Jae-Wook Jeong

O-104: Endometrial Mitochondrial DNA Secreted in Extracellular Vesicles: A Novel Mechanism Modulating Maternal-Embryo Bioenergetics
David Bolumar, Alicia Amadoz, Inmaculada Moreno, Carlos Marín, Antonio Diez, Jorge Jiménez-Almazán, Carlos Simón, Felipe Vilella

O-105: Entosis Occurs in Human Embryo Implantation
Andrea Palomar, Roberto Gonzalez-Martin, Stefania Salsano, Silvia Pérez-Debén, Alicia Quiñonero, Francisco Domínguez

O-106: MicroRNA Expression in Pregnancy of Unknown Location (PUL)
Christopher Kyriacou, Sung Hye Kim, Shabnam Bobdiwala, Phillip Bennett, Tom Bourne, Vasso Terzidou

Placenta II
Moderators: 
Carlos Salomon, PhD, DMedSc, MSc
Sarah J. Delforce, PhD

EAST MEETING ROOM 11 & 12 – VCC EAST LEVEL 2

O-107: Placental Genomic Imbalances Contribute to Poor Fetal Growth: From Trisomy to Copy Number Variants
Giulia F. Del Gobbo, Yue Yin, Sanaa Choufani, Emma A. Butcher, John Wei, Rosanna Weksberg, Ryan K.C. Yuen, Wendy P. Robinson

O-108: Transcription Factor NRF2 Serves a Key Role in the Expression of Immune Modulators During Human Trophoblast Differentiation
Youn-Tae Kwak, Sribalasubashini Muralimanoharan, Carole R. Mendelson

O-109: Placental Cell-specific Extracellular Vesicle Profiles from Syncytiotrophoblasts and Extravillous Trophoblasts in the First Trimester
Terry Morgan, Mayu Morita, Leslie Myatt

O-110: Bi-directional Signaling Between Placental Endothelial Cells and Extracellular Matrix Regulates Fetoplacental Angiogenesis in Severe Fetal Growth Restriction
Shuhan Ji, Diane Gumina, Kathryn Kilpatrick, Emily J. Su

O-111: Identifying Metabolite Signatures in Placental Development Using iHumanPlacenta Metabolic Network
Priyanka Baloni, Alison Paquette, Gina Huynh, Heather Brockway, Helen Jones, Yoel Sadovsky, Louis Muglia, Nathan D. Price

O-112: Trophoblast Derived Soluble-PDL1 Modulates Macrophage Polarization and Function
Gil G. Mor, Paulomi Aldo, Jiahui Ding,Yuan You, Janina Kaislasuo,Yonghong Zhang, Aihua Liao

Reproductive Endocrinology and Infertility II
Moderators: 
TBC
Lusine Aghajanova, MD, PhD

EAST MEETING ROOM 8 & 15 – VCC EAST LEVEL 2

O-113: Exposure to D-galactose is Not Embryotoxic
Mili Thakur, Bai David, Husam M. Abu-Soud

O-114: Examination of Androgen Effects on Female Reproductive Axis: Hypothalamus-Pituitary-Ovary
Sheng Wu, Olubusayo Awe, Mingxiao Feng, James Segars

O-115: Mild hyperandrogenemia in Presence/Absence of a High-fat, Western-style Diet Alters Secretory Phase Endometrial Transcriptome in Nonhuman Primates
Cecily Bishop, Fangzhou Luo, Lina Gao, Suzanne Fei, Ov Slayden

O-116: Effect of Mitochondrial Dynamin Like GTPase on Steroidogenesis in the Corpus Luteum
Michele R. Plewes, Pan Zhang, Xiaoying Hou, John Davis

O-117: Bioavailable Inhibin B May be a Better Marker of Oocyte Yield Than Ovarian Reserve
Rachel B. Danis, Intira Sriprasert, Jacqueline R. Ho, Lynda K. McGinnis, Ajay Kumar, Frank Z. Stanczyk

O-118: Dose-Dependent Ovulation Rates and Endocrine Correlates of Ovulation in PCOS Patients Undergoing Letrozole Ovulation Induction: A Secondary Analysis of the PPCOSII Trial
Tracy Nicole Hadnott Harrison, Alexander Quaas, R. Jeffrey Chang

Clinical and Translational Perinatology II
Moderators: 
Laxmi V. Baxi, MD
Kenneth K. Chan, MD

EAST MEETING ROOM 13 – VCC EAST LEVEL 2

O-119: First Use of an Artificial Placenta to Support Extremely Preterm Sheep Fetuses Compromised by Intrauterine Inflammation
Haruo Usuda, Matthew Kemp

O-120: Fetal Rh Antigen is Present Consistently Throughout Cells in the Maternal Circulation in Early Pregnancy
Stefanie J. Hollenbach, Mathew Cochran, Taylor Waldrop, Keelin Abbott, Amy Harrington

O-121: Individual Edinburg Perinatal Depression Scale (EPDS) Components and Preterm Birth
Shelby Smith, Talati Asha, Stephanie Sun, Robert Bradford, Hudson Santos, Tracy Manuck

O-122: Racial and Ethnic Disparities in Mode of Delivery During Labor Induction
Christina Ackerman, Masaru Negi, Uma Reddy, Lisbet Lundsberg, Audrey Merriam, Jessica Greenberg, Sarah Meller, Anna Sfakianaki

O-123: Maternal and Neonatal Morbidity Associated With TOLAC Versus Elective Repeat Cesarean as a Function of VBAC Success Prediction
Hayley Pierce, Frank B. Williams, Carole McBride, Kelley McLean

O-124: Maternal and Neonatal Morbidity Following Uterine Rupture by History of Previous Cesarean Section
Stephanie Sun, Asha Talati, Catherine Vladutiu, Tracy Manuck

6:15 p.m. - 7:30 p.m.

President's Address and Awards Ceremony

EAST BALLROOM BC - VCC EAST LEVEL 1

7:45 p.m. - 11:00 p.m.

The Featles Canadian Tour
*Ticketed event

EAST BALLROOM A - VCC EAST LEVEL 1

Registration

LOBBY - VCC EAST LEVEL 1

President's Distinguished Lecture II

EAST BALLROOM BC - VCC EAST LEVEL 1

Modeling Early Placental Development – Can Pluripotent Stem Cells Do the Trick?
Janet Rossant, CC, PhD, FRS, FRSC 
The Hospital for Sick Children and Department of Medical Genetics
University of Toronto, Toronto, ON Canada

9:00 a.m. - 10:30 a.m.

Poster Session III

EAST EXHIBIT HALL B - VCC EAST LEVEL 1

10:30 a.m. - 12:00 p.m.

Concurrent Oral Presentations IV

VARIOUS ROOMS

Fetus II
Moderators: 
Anna G. Euser, MD, PhD
Panicos Shangaris, MBBCh, BAO, MSc, MRCOG

EAST MEETING ROOM 13 – VCC EAST LEVEL 2

O-125: Late Gestation Fetal Hyperglucagonemia Results in Lower Fetal Weight, Fetal Hypoaminoacidemia, and Decreased Uteroplacental Nutrient Uptake
Sarah Cilvik, Stephanie R. Wesolowski, Russ V. Anthony, Laura D. Brown, Paul Rozance

O-126: Intrauterine Hypoxia Induces Compensatory Changes in Fetal Heart Function in Growth Restricted Fetuses in a Sex Dependent Manner
Loren P. Thompson, Shifa Turan, Graham W. Aberdeen

O-127: Maternal and Fetal Immunological Consequences of Intrauterine Inflammation: Implications for Fetal Brain Injury
Emma L. Lewis, Amy G. Brown, Natasha M. Tulina, Paige M. Porrett, Michal A. Elovitz

O-128: Novel Gasotransmitter Cardio-Protection in the Developing Heart: Comparative Roles of Hydrogen Sulphide and Carbon Monoxide
Y. Niu, Q. Lyu, R. M. Hess, S. G. Ford, T. A. Garrud, A. Iqbal, J. O. Louca, W. Tong, K. J. Botting, D. A. Giussani

O-129: Human Microglia Acquire a More Mature, Homeostatic Phenotype During the Transition of the First and Second Trimester of Gestation
Sharon Eskandar, Laura Kracht, Malte Borggrewe, Astrid M. Alsema, Nieske Brouwer, Michel Meijer, Susana M. Chuva de Sousa Lopes, Maaike C. Nieveen, Susanne M. Kooistra, Sicco A. Scherjon, Jelmer R. Prins, Bart J.L. Eggen

O-130: Bacterial and Viral Infections Inhibit Defence Mechanisms in the Developing Human Blood-Brain Barrier (BBB) in Vitro
Guinever E. Imperio, Petcharawan Lye, Enrrico Bloise, Stephen G. Matthews

Parturition III
Moderators: 
Matthew W. Kemp, PhD
TBC

EAST MEETING ROOM 8 & 15 – VCC EAST LEVEL 2

O-131: Extracellular Calcium Entry via the TRPV4 Channel Potentiates NFκB Activation in the Myometrium
Judith A. Ingles, Saidie Rodriguez, Lihua Ying, David N. Cornfield, Cristina M. Alvira

O-132: Synthetic PreImplantation Factor (sPIF) Prevents Preterm Birth and Preserves Fetal Brain Development
Marialuigia Spinelli, Cèline Boucard, Fiorella Di Nicuolo, Roberta Castellani, Alfredo Pontecorvi, Giovanni Scambia, Chiara Granieri, Eytan Barnea, Daniel Surbek, Nicoletta Di Simone, Martin Mueller

O-133: Exosomal Delivery of NF-kB Inhibitor Delays LPS-Induced Preterm Birth and Reduces Fetal Inflammatory Response in Mouse Models
Samantha Sheller-Miller, Enkhtuya Radnaa, Dolores Quiroz, Kyungsun Choi, Steven J. Fortunato, Chulhee Choi, Ramkumar Menon

O-134: The Vaginal Immune Response, the Microbiome, and Their Interactions in Women Who Ultimately Deliver Preterm or at Term
Violetta Florova, Roberto Romero, Adi L. Tarca, Chaur-Dong Hsu, Kevin Theis, Nardhy Gomez-Lopez

O-135: Microbial Metabolites Compromise Epithelial Barrier Integrity: Potential Mechanisms by Which Non-Optimal Cervicovaginal Microbiota Lead to Preterm Birth
Kristin D. Gerson, Yusra Gimie, Lauren Anton, Michal A. Elovitz

O-136: Fetal Membrane-Activated Neutrophils Propagate Fetal Membrane Inflammation and Markers of Membrane Weakening
Mancy Tong, Abigail H Smith, Vikki M. Abrahams

Placenta III
Moderators: 
Denise G. Hemmings, PhD
David Owen, MD, PhD

EAST MEETING ROOM 11 & 12 – VCC EAST LEVEL 2

O-137: In Vivo Impact of Chorionic Somatomammotropin RNA Interference in the Absence of Intrauterine Growth Restriction
Amelia R. Tanner,Ashgar Ali, Quinton A. Winger, Paul J. Rozance, Russell V. Anthony

O-138: Identification of Placental MiRNA Associated with Maternal Insulin Sensitivity During Pregnancy
Fernanda Alvarado, William Beyer, Tianjiao Chu, Yoel Sadovsky, Patrick Catalano, Marie-France Hivert, Perrie O'Tierney-Ginn

O-139: Changes in Lipid Profiles of Placental Exosomes in Maternal Plasma Characterize Pregnancies with a Small-for-Gestational Age Fetus
Miira M. Klemetti, Porter R. Tyler, Ante B.V. Pettersson, Martin Post, Isabella Caniggia

O-140: Azithromycin Treatment of Placental Inflammation in a Non-Human Primate Model of Intra-Amniotic Ureaplasma Infection
Meredith A. Kelleher, Terry K Morgan, Ji Yeon Lee, Victoria H.J. Roberts, Antonio E. Frias, Irina Burd, Miles J. Novy

O-141: MRI Compatible Ex-vivo Human Whole Placenta Dual Perfusion System
Shahin Rouhani, Jeffrey N. Stout, Esra Abaci Turk, Christopher G. Ha, Lawrence L. Wald, William H. Barth, P. Ellen Grant, Drucilla J. Roberts

O-142: Circulating CD31+ Exosomes From Pregnant Women with Placenta Accreta Spectrum Stimulate Uterine Angiogenesis and Trophoblast Differentiation and Invasion
Q.R. QI, J. Makhoul, Q.W. Zhang, J. Bai, Y. Li, Y.H. Yang, D.B. Chen

Reproductive Biology III
Moderators: 
Caroline E. Gargett, PhD
Bo Yu, MD

EAST MEETING ROOM 2 – VCC EAST LEVEL 2

O-143: G-CSF Mobilized Plasma Regenerate Ovarian Stroma and Restore Ovarian Function
Anna Buigues, Maria Marchante, Jessica Martínez, Antonio Pellicer, Sonia Herraiz

O-144: Modeling Preeclampsia Using Human Induced Pluripotent Stem Cells
Mariko Horii, Tony Bui, Ojeni Touma, Louise C. Laurent, Mana Parast

O-145: Pluripotent Stem Cell Derived Endometrial Mesenchyme and Decidual Epithelium Form a 3-Dimensional Model of the Human Endometrium
Virginia Chu Cheung, Mirna Marinic, Chian-yu Peng, Vincent J. Lynch, John A. Kessler

O-146: A Single-cell RNA-Seq Survey of Mouse Implantation Site Mapping the Contribution of Maternal Exogenous Bone Marrow Cells to Decidua
Reshef Tal, Jacqueline Kisa, Francesc Lopez-Giraldez, Avraham Unterman, Hugh S. Taylor

O-147: miR-155 Deficiency Impairs Pregnancy Tolerance and Predisposes to Inflammation-Induced Fetal Loss in Mice
Sarah A. Robertson, John S. Schjenken, Lachlan M. Moldenhauer, Bihong Zhang, Holly M. Groome, Hon Yeung Chan, Alison S. Care

O-148: Human Regulatory T Cells at the Maternal-Fetal Interface Show Functional Site-Specific Adaptation with Tumor-Infiltrating-Like Features
Judith Wienke, Laura Brouwers, Michal Mokry, Femke van Wijk, Bas B. Van Rijn, On Behalf of the SPAR Study Group

Preeclampsia II
Moderators: 
Shannon A. Bainbridge, PhD
Jenny Myers, PhD

EAST MEETING ROOM 1 – VCC EAST LEVEL 2

O-149: Can WS1442 Ameliorate Maternal Vascular Dysfunction in Preeclampsia?
Stephanie A. Worton, Yasmin Mills, Susan L. Greenwood, Jenny E. Myers

O-150: Effect of Pregnancy Prolongation in Early-Onset Preeclampsia on Remote Maternal Cardiovascular, Renal and Metabolic Function
Eva G. Mulder, Chahinda Ghossein, Janneke Crutsen, Sander M.J. van Kuijk, Baskaran Thilaganathan, Marc E.A. Spaanderman

O-151: Using Machine Learning Tools to Classify and Predict Preeclampsia in Asymptomatic Women
Jianhong Zhang, Melanie Audette, Nir Melamed, Stephen J. Lye, John C. Kingdom, Kelsey McLaughlin

O-152: Galectin-7: A Novel Placental-released Driver of Preeclampsia
Ellen Menkhorst, Wei Zhou, Teresa So, Leilani Santos, Jian-Guo Zhang, Argyro Syngelaki, Kypros Nicolaides, Yves St-Pierre, Eva Dimitriadis

O-153: The New Generation Antiplatelet Agent Prasugrel Represents an Exciting Novel Candidate Therapy for Preeclampsia
Natasha De Alwis,Natalie Binder, Sally Beard, Vi Nguyen, Kaitu'u-Lino Tu'uhevaha, Stephen Tong, Natalie Hannan

O-154: Identification of Subtype-specific Markers for Preeclampsia Using Placental Pathology and RNAseq
Mariko Horii, Cuong To, Rebecca Adami, Kathy Zhang-Rutledge, Leah Lamale-Smith, Louise C. Laurent, Mana Parast

Gynecologic Oncology
Moderators: 
Gloria S. Huang, MD
Erin George, MD

EAST MEETING ROOM 3 – VCC EAST LEVEL 2

O-155: Evaluation of ATR Inhibitors for Targeted Therapy of Ovarian Clear Cell Carcinoma
Jing Ji, Zhigui Li, Emily Sherman, Oloruntoba Osagie, Shijun Mi, Gloria Huang

O-156: The Expression of FKBP5 is Important to Overcome Progesterone Resistance in Endometrial Hyperplasia
Munseok Paul Jeong, Hanna E. Teasley, Tae Hoon Kim

O-157: Identifying a Potential Biomarker for Anti-PD-1 Immunotherapy in Patients with Advanced Stage, Surgically-Resectable Endometrial Cancer
Katherine C. Fuh, Elena Lomonosova, Lei Guo, Wendy J. Fantl, Russell K. Pachynski, Olga Malkova, Stephen T. Oh, Andrea R. Hagemann, Carolyn K. McCourt, Matthew Powell, Premal H. Thaker

O-158: Excess Adiposity Induces Intrauterine Cytochrome P450 Expression in Mice
Emily Xiao, Dejian Zhao, Clare Flannery

O-159: Differential Sensitivity to the PARP Inhibitor Niraparib vs Olaparib in Homologous Recombination Proficient (HRP) Uterine Serous Carcinoma Cell Lines
Joan Rose Tymon-Rosario, Paola Manara, Aranzazu Manzano, Luca Zammataro, Elena Bonazzoli, Stefania Bellone, Ludmil Alexandrov, Emanuele Perrone, Burak Zeybek, Chanhee Han, Gary Altwerger, Gulden Menderes, Elena Ratner, Dan-Arin Silasi, Gloria Huang, Azodi Masoud, Peter Schwartz, Alessandro D. Santin

O-160: Genetic Relationship Between Endometriosis and Ovarian Cancer Subtypes
Sally Mortlock, Kate Lawrenson, Simon Gayther, Stuart Macgregor, Paul Pharoah, Grant Montgomery, Siddhartha Kar

12:05 p.m. - 1:35 p.m.

Hot Topics and Awards Ceremony
*Boxed lunches will be provided.

EAST BALLROOM BC - VCC EAST LEVEL 1