Society of Reproductive Investigation (SRI)

O-001: Inhibition of the Chemokine Response Prevents Preterm Labor but Not an Invasive Infection in a Nonhuman Primate Model
Michelle Coleman

O-002: Novel Non-Classic Progesterone (P4) Receptor PGRMC1 Interactions and Functionality Reveal a Key Role During the Human Decidualization Process
Stefania Salsano

O-003: Placenta-Derived Fetal Circulating Factors in Pregnancies Complicated by Maternal Obesity Induce Cardiomyocyte Hypertrophy In Vitro
Owen R. Vaughan, PhD

O-004: ARID1A Loss Results in Non-Receptive Endometrium with FOXA2 Deficiency in Endometriosis-Related Infertility
Ryan M. Marquardt

Insights Into Drug Discovery and Development in Women’s Health: From Target Ideas to Molecules, to Medicine
Moderators: 
Dineo Khabele, MD
Andrew Blanks, BSc, PhD

Genome Editing and the Future of Reproduction 
Moderators: 
Erin Greaves, PhD
Monica Mainigi, MD

Anti-Mullerian Hormone/Müllerian Inhibiting Substance; Coming Home to France
Eligible for 1.0 European CME credits (ECMEC®s)/1.0 AMA PRA Category 1 Credits^TM
Moderators: 
Jose Teixeira, PhD
Nathalie diClemente, PhD
Room 242AB - Palais des Congrès

Rodent Models of PCOS
Chrystèle Racine, PhD

2:15 p.m. - 2:45 p.m.

Mechanisms of Female Fertility Preservation by AMH/MIS During Chemotherapy
David Pepin, PhD

2:45 p.m. - 3:15 p.m.

Impact of AMH and AMHR2 Genetic Variation on the Polycystic Ovary Syndrome Phenotype
Margarit Urbanek, PhD

3:15 p.m. - 3:45 p.m.

AMH and the Neuronal Control of Reproduction: From Physiology to Pathophysiology
Paolo Giacobini, PhD

What Can Pregnancy Reveal About Maternal Cardiovascular Risk
Eligible for 1.0 European CME credits (ECMEC®s)/1.0 AMA PRA Category 1 Credits^TM
Moderators: 
Janet Catov, PhD
Alisse Hauspurg, MD
Ampi Bleu - Palais des Congrès

Is Infertility a Cardiovascular Phenotype?
Jacob Udell, MD

Deep Phenotyping of Pregnancy Adaptation
Ira Bernstein, MD

2:45 p.m. - 3:15 p.m.

Adverse Pregnancy Outcomes: Markers or Causes of Cardiovascular Risk?
Abigail Fraser, PhD

3:15 p.m. - 3:45 p.m.

The Placenta As a Window to Future Maternal Cardiovascular Disease
Janet Catov, PhD

SRI-PRS Joint Session: Novel Imaging Techniques to Define Placental Function
Eligible for 1.0 European CME credits (ECMEC®s)/1.0 AMA PRA Category 1 Credits^TM
Moderators:
Dinesh M. Shah, MD
David Weinberg, PhD
Room 241 - Palais des Congrès

Total Uterine Blood-flow by Ultrasound and 4D MRI as a Measure of Placenta Function
Dinesh Shah, MD

2:15 p.m. - 2:45 p.m.

Placental Perfusion and Oxygenation by MRI
Antonio Frias, MD

2:45 p.m. - 3:15 p.m.

Fetal Villous Blood Flow and Placental Perfusion by Ultrasound
Tony Odibo, MD, MSCE, FRCOG, FACOG

3:15 p.m. - 3:45 p.m.

Fully Automated, Real-Time Multiclass Segmentation of the Utero-Placental Unit: Volumes and Vascularity
Sally Collins, MD, PhD

From Cells to Systems: Implications for Reproductive Immunological Health
Eligible for 1.0 European CME credits (ECMEC®s)/1.0 AMA PRA Category 1 Credits^TM
Moderators:
Hilary Gammill, MD
Brice Gaudilliere, MD
Room 251 - Palais des Congrès

Immune System Development During the First Weeks of Life in Term and Preterm Children
Petter Brodin, MD, PhD

2:15 p.m. - 2:45 p.m.

Time, Space, Identity, Specificity: A 4D View of Tregs at Work in Maternal-Fetal Tolerance
David Klatzmann, MD, PhD

2:45 p.m. - 3:15 p.m.

Microchimerism: Extension of Maternal-Fetal Interactions Over Time
Hilary Gammill, MD

3:15 p.m. - 3:45 p.m.

Immune System Adaptations in Pregnancy: It’s All About Timing
Brice Gaudilliere, MD

Advances in Prenatal Molecular Screening: The Innovation That Transformed Prenatal Care
Eligible for 1.0 European CME credits (ECMEC®s)/1.0 AMA PRA Category 1 Credits^TM
Moderators:
Christina S. Han, MD
Diana Bianchi, MD 
Room 252B - Palais des Congrès

NIPS: The Science, Utility, and Limitations
Lawrence D. Platt, MD

2:15 p.m. - 2:45 p.m.

If NIPS Is So Good, Why Aren’t All Pregnant Women Benefiting?
Glenn E. Palomaki, PhD

2:45 p.m. - 3:15 p.m.

Tissue of Origin Analyses of Cell-Free DNA to Decipher Pathologies in the Fetus and the Mother
Rossa Chiu, MD

3:15 p.m. - 3:45 p.m.

Innovation: New Technologies to Detect Rare Fetal and Placental Cells in the Circulation
Yalda Afshar, MD, PhD

Environmental Influences on Pregnancy and Health Outcome: Informing on New Strategies for Disease Prevention
Eligible for 1.0 European CME credits (ECMEC®s)/1.0 AMA PRA Category 1 Credits^TM
Moderators:
Tracy Manuck, MD
Francisco Dominguez Hernandez, PhD
Room Maillot - Palais des Congrès

Prenatal Arsenic Exposure and the Epigenome: Informing Disease Mechanisms and the Risk Assessment Process
Rebecca C. Fry, PhD

2:15 p.m. - 2:45 p.m.

Effects of Exposure to Diesel Exhaust During Pregnancy on Feto‐Placental and Offspring Development Using a Rabbit Model
Pascale Chavatte-Palmer, DVM, PhD

2:45 p.m. - 3:15 p.m.

Phthalates Impair Villous Trophoblast Differentiation and Endocrine Functions Through Activation of the Nuclear Receptor PPARgamma
Thierry Fournier, PhD 

3:15 p.m. - 3:45 p.m.

Reproductive and Pregnancy Outcomes of Patients Treated with Alkylating Chemotherapy
Lynae Brayboy, MD

Clinical Perinatology I 
Moderators:
Roger C. Young, MD, PhD
Linda Chambliss, MD, MPH
Room 252B - Palais des Congrès

O-005: Measuring Intrapartum Fetal Tissue Oxygen Saturation during Abnormal Fetal Heat Rate Patterns
Naohiro Kanayama, Kenta Kawai, Toshiyuki Uchida, Mari Mukai, Kazunao Suzuki, Hiroaki Itoh

O-006: Pregnancy Outcome following Zika Virus (ZIKV) Infection during the 3rd Trimester in the Olive Baboon (Papio Anubis): Evidence Does Not Support a Protective Role for Type III Interferons
Sunam Gurung, Darlene Reuter, Marta Maxted, Krista Singleton, Kim Hyatt, Ashley Martin, Jamie Dubaut, Alisha Preno, James Papin, Dean Myers

O-007: Women Entering Pregnancy with Newly Defined Stage 1 Hypertension are at Increased Risk for Preeclampsia
Elizabeth F. Sutton, Samia Lopa, Sarah C. Rogan, Danielle Sharbaugh, Janet Catov

O-008: First Achievement of Successful Maintenance in 95 Days Extremely Preterm Lambs Treated with Ex Vivo Uterine Environment (EVE) Therapy
Haruo Usuda, Shimpei Watanabe, Mastoshi Saito, Gabrielle Musk, Tsukasa Takahashi, Yusaku Kumagai, Shinichi Sato, Takushi Hanita, John Newnham, Matthew Kemp

O-009: Exposure to Low Levels of Combined Air Pollutants in Both the First and Second Trimester is Associated with Increased Risk of Preterm Birth (PTB) in High-Risk Women in North Carolina
R. Dhingra, L. Smeester, J. Rager, W. Vizuete, R. C. Fry, T. A. Manuck

O-010: Analysis of the Microbiome in Cord Blood from Live Births and Stillbirths
Emilie Vander Haar, Tal Korem, Huiying Li, Cynthia Gyamfi-Bannerman, Uma Reddy, Ronald Wapner, Robert Goldenberg, Stillbirth Collaborative Research Network, Yiping W. Han

O-011: First Trimester AFP:PAPP-A Ratio in the Prediction of Adverse Pregnancy Outcome
Ulla Sovio, Francesca Gaccioli, Alice E. Hughes, D. Stephen Charnock-Jones, Gordon C.S. Smith

O-012: Performance of a Maternal Abdominal Surface Electrode System for Fetal Heart Rate Monitoring from 34 to 37 Weeks
Maritza G. Gonzalez, Meghan G. Hill, Raheleh Mohammadi, Pegah T. Hosseini, Wayne R. Cohen

Gynecology I 
Moderators:
Ayman Al-Hendy, MD, PhD
Erin Greaves, PhD
Room Maillot - Palais des Congrès

O-013: Degradable Nanostructured Mesh and Endometrial Stem/Stromal Cells AsA Bioengineered Construct for Pelvic Organ Prolapse
Shayanti Mukherjee, Saeedeh Darzi, Vinod Kadam, Yen Truong, Anna Rosamilia, Jerome Werkmeister, Caroline Gargett

O-014: Injectable Collagenase Clostridium Histolyticum (EN3835) for Uterine Fibroids: Results of a Phase 1 Clinical Trial
Bhuchitra Singh, Szu-Chi Su, Thomas Wegman, Joshua Brennan, Irene Trueheart, Holly Sims, Jean-Marie Soma, Rosina Dixon, Phyllis Leppert, Barbara Smith, James Segars.

O-015: Pleiotropic Associations between a Uterine Leiomyoma Polygenic Risk Score (PRS) and the Clinical Phenome
Jacklyn N. Hellwege, Eric S. Torstenson, Todd L. Edwards, Digna R. Velez Edwards

O-016: Aberrant Trophoblast-Endometrial Cross-Talk in Endometriosis
Sahar Houshdaran, Tamara Zdravkovic, Susan Fisher, Linda Giudice

O-017: Mutations in METTL11B: A Primer for N-Terminal RCC1 Methyltransferase Play a Role in Endometriosis
Rakesh Chettier, Hans Albertsen, Kenneth Ward

O-018: NGS of Oocytes from Endometriosis Patients Reveals a Differential Transcriptomic Pattern
Hortensia Ferrero Chafer, Ana Corachán, Alicia Quiñonero, Maria Cristina Carbajo-García, Pilar Alamá, Alberto Tejera, Esther Taboas, Elkin Muñoz, Antonio Pellicer, Francisco Dominguez

O-019: Acute DEHP Exposure in Endometrial Epithelial Cells Does Not Phenocopy the Alterations Described in Endometriosis
Roberto Gonzalez-Martin, Alicia Quiñonero, Silvia Perez-Deben, Stefania Salsano, Francisco Dominguez

O-020: Avoiding False Positive Results through Ancestry Filtering
Hans M Albertsen, Rakesh Chettier, Kenneth Ward

Maternal Biology and Health 
Moderators:
Lorna G. Moore, PhD
Nga Ling Ko, PhD
Room 251 - Palais des Congrès

O-021: High Altitude Increases Vasodilatory Response to Pharmacologic PPARg Activation in Murine Uterine and Human Myometrial Arteries
Sydney L. Coates, Ramon A. Lorca, Lorna G. Moore, Colleen G. Julian

O-022: Pregnancy Increases Uterine Blood Flow via ERbeta Dependent AT2R-Mediated Mechanism
Gigi M te Riele, Jay S Mishra, Kathir Gopalakrishnan, Sathish Kumar

O-023: Maternal Mesenteric Artery Structural Parameters Approximate the Non-Pregnant State by 12 Weeks Postpartum in Mice
Natalia I. Gokina, Rebecca I. Fairchild, Nicole M. Bishop, Taylor E. Dawson, Kirtika Prakash, Elizabeth A. Bonney

O-024: Influenza A Virus Infection during Pregnancy Induces Severe Maternal Vascular Dysfunction and Fetal Growth Restriction
Stella Liong, Kurt Brassington, Osezua Oseghale, Eunice To, Felicia Liong, Jonathan Erlich, Raymond Luong, Steven Bozinovski, John J. O’Leary, Doug A. Brooks, Ross Vlahos, Stavros Selemidis

O-025: The Vaginal Microbiome as a Predictor for Outcome of In-Vitro Fertilization with or without Intracytoplasmic Sperm Injection: A Prospective Study
Rivka Koedooder, Martin Singer, Sam Schoenmakers, Paul Savelkoul, Servaas Morré, Jonathan de Jonge, Linda Poort, Willem-Jan Cuypers, Andries Budding, Joop Laven, ReceptIVFity Study Group

O-026: Effect of Gestational Diabetes Mellitus on Long Term Maternal Health in a Novel Mouse Model
Kathleen A. Pennington, Simone Hernandez Ruano, Haleh Sangi-Haghpeykar

O-027: Effect of Pregnancy on Maternal Endothelial Glycocalyx Later in Life
Judith Brands, Marcia J. Gallaher, Robert W. Powers

O-028: Lactation and Association with Maternal Gut Microbiome
Adetola F. Louis-Jacques, Thao T.B. Ho, Anujit Sarkar, Maureen W. Groer

Parturition I 
Moderators:
Tamas Zakar, MD, PhD
Nardhy Gomez-Lopez, PhD
Room 242AB - Palais des Congrès

O-029: Decidual Stromal Cells and Cytotrophoblasts Synergize to Dampen and Modulate Macrophage Activation in Response to Group B Streptococcus Infection
Alison J. Eastman, Lisa M. Rogers, Kevin G. Osteen, David M. Aronoff

O-030: The Placenta Exhibits Selective Immune Response in an In Vitro Model of Haematogenous Multi-Pathogen Induced Preterm Labour
Zahirrah B. Mohammed Rasheed, Camino Ruano San Martin, Mark H.F. Sullivan, Eberechi Anucha, Yun S. Lee, Phillip R. Bennett, David A. MacIntyre, Lynne Sykes

O-031: A Cellular Regenerative Approach to Prevent Preterm Birth: In Vitro M2-Polarized Macrophages
Valeria Garcia-Flores, Roberto Romero, George Schwenkel, Sonia Hassan, Nardhy Gomez-Lopez

O-032: The Effects of Cervical Epithelial Damage-Mediated Ascending Infection with Ureaplasma Parvum on Intreauterine Inflammation and Timing of Delivery
Ioannis Pavlidis, Brad O. Spiller, Gabriella S. Demarco, Sarah E. M. Howie, Jane E. Norman, Sarah J. Stock

O-033: The Role of WNT Signaling in Placental Development and Birth Timing
Ortal Tamam, Ruti Parvari, Kaulini Burra, Debora Sinner, Louis J. Muglia

O-034: The Local and Systemic Immune Response in Preterm and Term Pregnancies and Their Association with the Vaginal Microbiota
Denise Chan, Yun S. Lee, Saqa Ahmed, T.G. Teoh, Phillip R. Bennett, David A. MacIntyre, Lynne Sykes

O-035: Fetal Immune Cell Trafficking to Maternal Uterine Tissues in Animal Models of Term and Preterm Labor.
Samantha Sheller-Miller, Ramkumar Menon

O-036: Mechanism of Adverse Interaction between Iron and Inflammation during Pregnancy
Allison L. Fisher, Veena Sangkhae, Nicolaos Palaskas, Tomas Ganz, Elizabeta Nemeth

Preeclampsia I 
Moderators:
Virginia D. Winn, MD, PhD
Robert W. Powers, PhD
Ampi Bleu - Palais des Congrès

O-037: Early Onset of Coronary Artery Calcification in Women with Previous Preeclampsia
Laura Benschop, Laura Brouwers, Gerbrand A. Zoet, Cindy Meun, Eric Boersma, Ricardo P.J. Budde, Bart C.J.M. Fauser, Christiane M.J. de Groot, Angela H.E.M. Maas, Hans J. Duvekot, Birgitta K. Velthuis,Arie Franx, Eric Steegers, Bas B. van Rijn, Jeanine E. Roeters van Lennep

O-038: Antiphospholipid Antibodies Induce ROS Production in First Trimester Placentae: A Contribution to the Pathogenesis of Preeclampsia
Rachel Zussman, Lance Xu, Katie Groom, Blake M. Seers, Qi Chen, Jaijjus P. Johny, Lawrence W. Chamley, Anthony J.R. Hickey

O-039: Compromised JMJD6 Activity Due to Placental Iron Deficiency Underlies Aberrant Fibronectin Processing in Preeclampsia
Sruthi Alahari, Leonardo Ermini, Martin Post, Isabella Caniggia

O-040: High Levels of Circulating HtrA4 in Preeclampsia May Induce Endothelial Cell Cycle Arrest and Inhibit Endothelial Repair
Yao Wang, Rebecca Lim, Guiying Nie

O-041: Human Placental Bed Endothelial Cell Transcriptomics and Systemic Biomarker Profiling Reveals Inflammatory Endothelial Activation in Early Onset Preeclampsia
Laura Brouwers, Judith Wienke, Michal Mokry, Peter GJ. Nikkels, Tatjana E. Vogelvang, Arie Franx, Femke van Wijk, Bas B. van Rijn

O-042: New Generation Antiplatelet Agents Mitigate Pathophysiological Aspects of Preeclampsia in Both Human and Mouse Models of Preeclampsia, Representing Exciting Novel Candidate Therapeutics
Natalie Hannan, Sally Beard, Natalie Binder, Natasha De Alwis, Natasha Pritchard, Tu'uhevaha Kaitu'u-Lino, Stephen Tong

O-043: Platelet IFITM3 Contributes to Thrombosis in Preeclampsia
Heather D. Campbell, Bhanu K. Manne, Neal D. Tolley, Christian C. Yost, Robert A Campbell

O-044: Estradiol-17β-Induced Temporal and Spatial Uterine Endothelial Caveolar Partitioning of Phosphorylated eNOS
Mayra B. Pastore, Dongbao Chen, Ronald R. Magness

Reproductive Biology I 
Moderators:
Steven L. Young, MD, PhD
Mary Louise Hull, PhD, MBChB
Room 241 - Palais des Congrès

O-045: Homeostatic Readjustment of the Secretory Pathway during Decidualization of Endometrial Stromal Cells
Paola Panina-Bordignon, Tiziana Anelli, Eelco van Anken, Claudia Semino

O-046: Mechanisms Involved in Relaxation Responses of Uterine Artery from Pregnant Women to the Family of Calcitonin Gene Related Peptides
Madhu Chauhan, Ancizar Betancourt, Meena Balakrishnan, Chandra Yallampalli

O-047: Serum Cytokines Related to Endometriosis in Patients with Multiplex Immunoassay

Heeyon Kim1, Jeong Sook Kim1, Ji Hyun Park1, Jae Hoon Lee1, Bo Hyon Yun1, Seok Kyo Seo1, Joo Hyun Park1, SiHyun Cho1*, Young Sik Choi1, Byung Seok Lee1, Jong Baek Lim2, Jung Ho Shin3

1. Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea
2. Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea
3 Department of Obstetrics and Gynecology, Korea University College of Medicine, Seongbuk-gu, Seoul, South Korea"

O-048: Maternal Loss of NLRP2 Results in Abnormal Reproductive Outcomes Independent of the Uterine Environment
Sara Arian, Sangeetha Mahadevan, Hadi Erfani, Rajesh Ramakrishnan, Lan Liao, Katherine Shelly, Ignatia Van den Veyver

O-049: C-Type Natriuretic Peptide Signaling in Human Follicular Environment and Its Relation with Oocyte Maturation
Maira Casalechi, Lorena P. Velozo, Veronica N. Lobach, Ines K. Cavallo, Cynthia Dela Cruz, Fernando M. Reis

O-050: Deciphering Molecular Pathways that Initiate Primordial Follicle Growth in Human Ovary: A Single Oocyte RNA Sequencing Study.
Shiny Titus, Enes Tylan, Kutluk Oktay

O-051: Evaluating Cervical Mucus Production Using Conditionally Reprogrammed Endocervical Cells
Leo Han, Walker Andrews, Shan Yao, Jeffrey T. Jensen

O-052: Drug-Target Model for Discovering and Personalizing Endometriosis Therapies
Pablo Garcia-Acero, Patricia Sebastian-Leon, Alejandro Aleman, Almudena Devesa-Peiro, Patricia Diaz-Gimeno

Developmental Programming I
Moderators:
Pascale Chavatte-Palmer, DVM, PhD
Sathish Kumar, DVM, PhD
Room 241 - Palais des Congrès

O-053: Cardio-Protective Actions of Carbon Monoxide in the Developing Heart via Activation of MitoKATP Channels
Q. Lyu, Y. Niu, S. G. Ford, W. Tong, T. A. Garrud, K. J. Botting, J. Ma, D. A. Giussani

O-054: Antenatal Betamethasone Increases Genome-Wide DNA Access in a Dose-, Tissue-, and Gestational Age Specific Manner in Preterm Lambs
Erin Zinkhan, Baifeng Yu, Christopher Callaway, Kurt Albertine, Robert McKnight

O-055: Perinatal Iron-Deficiency and a High-Salt Diet Cause Long-Term Sex-Dependent Hypertension, Renal Mitochondrial Dysfunction and Oxidative Stress
Andrew G. Woodman, Richard Mah, Danae L. Keddie, Ronan M.N. Noble, Sareh Panahi, Ferrante S. Gragasin, Hélène Lemieux, Stephane L. Bourque

O-056: Norepinephrine Spares Adipose Tissue in Ovine Fetuses Complicated with Placental Insufficiency
Rosa I Luna Ramirez, Amy C. Kelly, Christopher A. Bidwell, Melissa A. Davis,Leticia E. Camacho, Miranda J. Anderson, Sean W. Limesand

O-057: Childhood Adiposity and Cardiovascular Outcomes at 3 Years Following a Randomised Controlled Trial of a Behavioural Intervention in Obese Pregnant Women (the UPBEAT Trial)
Kathryn V. Dalrymple, Majella O'Keeffe, Keith M. Godfrey, Claire Singh, Annette L. Briley, Paul T. Seed, Angela C. Flynn, Lucilla Poston

O-058: Repression of the Glucocorticoid Receptor Worsens Hypoxic-Ischemic Brain Injury in the Male Neonatal Rat
Katherine R Knox-Concepcion, Johnny D. Figueroa, Richard E. Hartman, Yong Li, Lubo Zhang

Fetus I
Moderators:
Karin J. Blakemore, MD
Julia C. Shaw, PhD
Room 251 - Palais des Congrès

O-059: Pregestational Maternal Diabetes-Increased miR-142 Contributes to Endoplasmic Reticulum Stress and Congenital Heart Defects by Targeting Lysine Acetyltransferases
Daoyin Dong, Peixin Yang

O-060: A Multidisciplinary Strategy for Identification of Novel Candidate Genes in Prenatal Cases with Congenital Anomalies of the Kidney and Urinary Tract
Neeta L. Vora, Julie K. Holsclaw, Kelly Gilmore, Erica E. Davis

O-061: Apigenin as a Candidate Prenatal Treatment for Trisomy 21: Effects in Human Amniocytes and the Ts1Cje Mouse Model
Diana W. Bianchi, Jeroen L. Pennings, Ashley Siegel, Fatimah Alsebaa, Uma Tantravahi, Faycal Guedj

O-062: The Relationship between Histologic Funisitis and Biomarkers to Identify Neonates at Increased Risk of Brain Injury
Ahizechukwu C. Eke, Frances F. Northington, Allen A. Everett, Dhananjay D. Vaidya, Lavisha L. McClarin, Ernest Graham

O-128: Decreased Complex 1 Expression and Impaired Mitochondrial Function in Growth Restricted Ovine Fetuses with Placental Insufficiency
Alexander L. Pendleton, Melissa A. Davis, Amy C. Kelly, Leticia E. Camacho, Miranda J. Anderson, Sean W. Limsand

O-064: Placental Insufficiency Suppresses Fatty Acid Transport Proteins in the Fetal Heart
Rachel Drake, Samantha Louey, Kent L. Thornburg

Gynecology II
Moderators:
William H. Catherino, MD, PhD
Dharani K. Hapangama, BSc, MD, MRCOG
Ampi Bleu - Palais des Congrès

O-065: Heterogeneous Overexpression of HES6 Promotes the Growth of Uterine Leiomyomas
Joie Z. Guner, Venkata A. Jonnalagadda, Ninad M. Patil, Ramya P. Masand, Cecilia T. Valdes, William E. Gibbons∗, Matthew L. Anderson

O-066: A Non-Surgical Murine Model of Endometriosis-Associated Pain that Predicts Response to Clinically Active Drugs
Victor Fattori, Noah S. Franklin, Rafael Gonzalez-Cano, Danielle Peterse, Erika Madrian, Waldiceu A. Verri Jr., Nick Andrews, Clifford J. Woolf, Michael S. Rogers

O-067: Urinary Concentrations of Bisphenols in Relation to Uterine Leiomyomata Risk
Amelia K. Wesselink, Jennifer Weuve, Russ Hauser, Paige L. Williams, Traci N. Bethea, Michael McClean, Quaker E. Harmon, Lauren A. Wise

O-068: DNA Methylation Dictates Leiomyoma Stem Cell Differentiation Through Regulating Hormone Receptor Signaling
Shimeng Liu, Ping Yin, Serdar E. Bulun

O-069: The Expression and Functional Role of Long Non-Coding RNA XIST in Leiomyomas
Tsai Der Chuang, Omid Khorram

O-070: YAP/TAZ are Activated by Mechanical and Hormonal Stimuli and Exhibit Increased Baseline Activation in Uterine Fibroids
MacKenzie P. Purdy, Andrew J. Haak, Merrick Ducharme, Jovanka Ravix, Daniel J. Tschumperlin, Y.S. Prakash, Qi Tan, Delphine Sicard, Elizabeth A. Stewart

Parturition II
Moderators:
Mark Phillippe, MD, MHCM
Emmanuel Amabebe, PhD
Room 242AB - Palais des Congrès

O-071: Amnion Membrane-Organ-On-Chip: An Innovative Approach to Study Cellular Interactions
Lauren Richardson, Sung Jin Kim, Arum Han, Ramkumar Menon

O-072: Serum Proteomics of Term and Spontaneous Preterm Delivery in South-Asian and Sub-Saharan-African Populations
R. Khanam, N. S. Boghossian, J. Burchard, U. Dhingra, M. I. Nisar, S. Yoshida, A. C. Fox, Sera Clinical Lab, T. C. Fleischer, J. J. Boniface, D. E. Hickok, R. Bahl, S. Sazawal, F. Jehan, A. H. Baqui, AMANHI Consortium

O-073: Diet-Induced Obesity Alters Baseline and Oxytocin-Stimulated Uterine Contractility in Mice
Antonina I. Frolova, Kevin K. Prifti, Jeremie L.A. Ferey, Michaela Reid, Kelle H. Moley, Sarah K. England

O-074: Enhancement of Cortisol-Induced SAA1 Transcription by SAA1 in Human Amnion Fibroblasts: Implications for Parturition
Wangsheng Wang, Yi Lu, Sun Kang

O-075: Labour Onset: A Consequence of Association Between PRA and ERα
Lubna Nadeem, Rathesh Balendran, Hedy Romero, Oksana Shynlova, Sam Mesiano, Stephen J. Lye

O-076: Amniotic Fluid Exposomics Identifies Novel Prenatal Exposures and Metabolic Signatures in Relation to Preterm Birth
Yunjia Lai, Kun Lu, Kim Boggess, Rebecca Fry, Neeta Vora

Placenta I
Moderators:
Sylvie Girard, PhD
David Owen, MD PhD
Room Maillot - Palais des Congrès

O-077: Novel Non-Invasive High Intensity Focused Ultrasound Treatment of Twin-Twin Transfusion Syndrome: Cardio-Metabolic Recovery
C. J. Shaw, I. Rivens, J. Civale, K. J. Botting, Y. Niu, G. ter Haar, C. C. Lees, D. A. Giussani

O-078: Modelling Haemodynamics in the Feto-Placental Vasculature of Control and Intrauterine Growth Restricted (IUGR) Rat Fetuses: Preliminary Data
Nikhilesh Bappoo, Andrew Evans, Lachlan J. Kelsey, Louis P. Parker, Yutthapong Tongpob, Carmel S, Moran, Adrian Thomson, Megan C. Holmes, Caitlin S. Wyrwoll, Barry J. Doyle

O-079: A Bioengineering Approach to Study Human Trophoblast Invasion
Yassen Abbas, Lucy Gardner, Ashley Moffett, Graham J. Burton

O-080: Maternal Decidual Cells Regulate Trophoblast Invasion: Studies from a Novel Organ-on-a-Chip Device
Monica A Mainigi, Sneha Mani, Cassidy Blundell, Ju Young Park, Rachel Young, Dongeun Huh

O-081: Placental TRPV2 Expression is Indispensable for Fetal Growth
Katrien De Clercq, Silvia Pinto, Evy Van Den Broek, Thomas Voets, Joris Vriens

O-082: Investigating the Impact of Herpes Simplex Virus Type 2 Infection on Pregnancy Outcomes in Mice
Allison M. Felker, Philip V. Nguyen, Charu Kaushic

Reproductive Endocrinology I
Moderators:
Donna R. Session, MD
Molly B. Moravek, MD, MPH
Room 252B - Palais des Congrès

O-083: Mitochondrial DNA Copy Number in Trophectoderm is Not a Predictive Biomarker for Human Embryo Viability
Richard Scott III, Li Sun, Jessica Landis, Yiping Zhan,Diego Marin, Xin Tao, Emre Seli

O-084: Epigenetic Alterations in Cytochrome P450 Oxidoreductase (Por) in Sperm Exposed to Tetrahydrocannabinol (THC)
Kelly S. Acharya, Rose Schrott, Edward Levin, Susan K. Murphy

O-085: Oral Vitamin D Supplementation Impacts Luteinized Granulosa Cell Transcriptomics
Sofia Makieva, Gianluca Puglisi, Francesca Bonesi, Elisa Giacomini, Alessio Paffoni, Veronica Sarais, Luca Pagliardini, Enrico Papaleo, Edgardo Somigliana

O-086: Euploid Pregnancy Loss Not Predicted by Embryo Morphokinetics
Dana McQueen, Dana Kimelman, Rafael Confino, Jared Robins, Lia Bernardi, John Zhang, Mary Ellen Pavone

O-087: Use of Fresh vs Frozen Embryos in Donor Cycles Results in Improved Birth Outcomes in the United States: A 2013-2015 National Study
Cassandra Roeca, Rachel Johnson, Nichole Carlson, Tracy Truong, Alex J. Polotsky

O-088: Results from a Large Retrospective Matched Cohort Study on the Impact of Endometriosis on Embryologic Parameters of an IVF Program
Ana M. Sanchez, Luca Pagliardini, Greta C. Cermisoni, Laura Privitera, Alessandra Alteri, Laura Corti, Elisa Rabellotti, Paola Vigano

Sharing Data, Ideas and Resources to Have an Impact on Perinatal Research
Moderators: 
James Roberts, MD
Arun Jeyabalan, MD

The Impact of Clinical Trials on Improving Reproductive Health
Moderator: 
Thomas McElrath, MD, PhD
Lucilla Poston, PhD

Genetics, Epigenetics and Metagenomics of Endometriosis: From Discovery to Therapeutics
Eligible for 1.0 European CME credits (ECMEC®s)/1.0 AMA PRA Category 1 Credits^TM
Moderators: 
Peter Rogers, PhD
Ramakrishna Kommagani, PhD
Ampi Bleu - Palais des Congrès

Heritable Genetics and Endometriosis
Krina Zondervan, MSc, DPhil

2:45 p.m. - 3:15 p.m.

Somatic Mutations and Evolution of Endometriosis Species
Ie-Ming Shih, MD, PhD

3:15 p.m. - 3:45 p.m.

Epigenetics and Endometriosis
Serdar E. Bulun, MD

3:45 p.m. - 4:15 p.m.

Endometriosis and the Gut Microbiota
Ramakrishna Kommagani, PhD

The Maternal Brain at Risk: Neurological Adaptations and Complications of Pregnancy
Eligible for 1.0 European CME credits (ECMEC®s)/1.0 AMA PRA Category 1 Credits^TM
Moderators: 
Marilyn J. Cipolla, PhD
Helen Feltovich, MD
Room 251 - Palais des Congrès

The Impact of Pregnancy and Preeclampsia on Brain Injury During Seizure
Marilyn J. Cipolla, PhD

2:45 p.m. - 3:15 p.m.

Cerebrovascular Autoregulation in Pregnancy and Preeclampsia
Eliza Miller, MD

3:15 p.m. - 3:45 p.m.

Brain Excitability Changes During Preeclampsia
Ingrid Brussé, MD, PhD

3:45 p.m. - 4:15 p.m.

Long-Term Cerebral Structural Changes After Preeclampsia
Timo Siepmann, MD

Developing Interventions That Address IUGR
Eligible for 1.0 European CME credits (ECMEC®s)/1.0 AMA PRA Category 1 Credits^TM
Moderators: 
Sean W. Limesand, PhD
Laura C. Schulz, PhD 
Room Maillot - Palais des Congrès

Loss of Myostatin Alleviates Growth Restriction Due to Osteogenesis Imperfecta
Laura C. Schulz, PhD

2:45 p.m. - 3:15 p.m.

Oxygen and Glucose Correction Improves Insulin Secretion in Sheep Fetuses with Placental Insufficiency
Sean W. Limesand, PhD

3:15 p.m. - 3:45 p.m.

Maternal Uterine Artery VEGF Gene Therapy for Treatment of IUGR Intrauterine Growth Restriction
Anna L. David, PhD

3:45 p.m. - 4:15 p.m.

Role of Statins in Preventing Placental Disorders of Pregnancy
Maged Costantine, MD

Group B Streptococcus: Bacterial Pathogenesis, Mechanisms of Fetal Injury and Vaccine Strategies
Eligible for 1.0 European CME credits (ECMEC®s)/1.0 AMA PRA Category 1 Credits^TM
Moderators: 
Kristina Adams Waldorf, MD
Stephen McCartney, MD, PhD
Room 252B - Palais des Congrès

Epidemiology of Group B Streptococcus and Adverse Perinatal Outcomes
Michael Gravett, MD

2:45 p.m. - 3:15 p.m.

GBS Virulence Factors and Preterm Birth
Lakshmi Rajagopal, PhD 

3:15 p.m. - 3:45 p.m.

Role of the Vaginal Microbiome in Colonization and Pathogenesis of Group B Streptococcus
Amanda Lewis, PhD

3:45 p.m. - 4:15 p.m.

Development of a Global GBS Vaccine: From Concept to Clinic
Lawrence Paoletti, PhD

Reproduction Meets Engineering
Eligible for 1.0 European CME credits (ECMEC®s)/1.0 AMA PRA Category 1 Credits^TM
Moderators: 
Shannon Hawkins, MD, PhD
Kristin Myers, PhD
Room 241 - Palais des Congrès

Organoid Modeling of Healthy and Diseased Endometrium
Hugo Vankelecom, PhD

2:45 p.m. - 3:15 p.m.

Bioengineering a 3D-Printed Bioprosthetic Ovary: A Promising Approach for Restoring Fertility and Normal Hormone Production in Surviving Cancer Patients
Monica Laronda, PhD

3:15 p.m. - 3:45 p.m.

Personalized Biomechanical Models of Pregnancy – An Engineering Perspective of Preterm Birth
Kristin Myers, PhD

3:45 p.m. - 4:15 p.m.

Electromyometrial Imaging (EMMI): A Noninvasive Technique to Measure Uterine Electrophysiology in Three Dimensions
Yong Wang, PhD

SRI-SSR Joint Session: Implications of Manipulating Immature Ovarian Follicles to Produce Healthy Mature Eggs
Eligible for 1.0 European CME credits (ECMEC®s)/1.0 AMA PRA Category 1 Credits^TM
Moderators:
Joshua Johnson, PhD
Amanda Kallen, MD
Room 242AB - Palais des Congrès

Controlling the Rate of Primordial Ovarian Follicle Growth Activation
Joshua Johnson, PhD

2:45 p.m. - 3:15 p.m.

Handling Human Ovarian Cortex to Maximize Future Function and Fertility
Francesca Duncan, PhD

3:15 p.m. - 3:45 p.m.

The Production of Mature Metaphase II Eggs from the Non-growing Pool of Cortical Ovarian Follicles
Marie McLaughlin

3:45 p.m. - 4:15 p.m.

Distinct Properties of Immature Follicles in Prepubertal and Adult Ovaries: An Implication of the Endocrine Environment?
Celine Julie Guigon

Clinical Perinatology II
Moderators:
Laura Goetzl, MD, MPH
Maritza G. Gonzalez, MD
Room 251 - Palais des Congrès

O-089: Exosomes Isolated from Women with Gestational Diabetes Cause Insulin Resistance and Fail to Stimulate Islet Insulin Secretion in Non-Pregnant Mice
Laura B. James-Allan, Fredrick J. Roasario, Kelsey Barner, David McIntyre, Martha Lappas, Theresa L. Powell, Carlos Salomon, Thomas Jansson

O-090: The Relationship between Maternal Glucose Variability during Pregnancy and Neonatal Birthweight Percentile in Pre-Gestational Diabetic Women
Nimrod Dori-Dayan, Tali Cukierman-Yaffe, Roni Zemet, Shali Mazaki-Tovi, Rakefet Yoeli-Ullman

O-091: Recurrence Risk of Hyperemesis Gravidarum in Successive Pregnancies
Michael J. Fassett, Deborah A. Wing, Sally F. Shaw, Theresa M. Im, Darios Getahun

O-092: Maternal Zika Virus (ZIKV) Infection Following Vaginal Inoculation with ZIKV Infected Semen in the Pregnant Olive Baboon
Hugh C. Nadeau, Marta Maxted, Sunam Gurung, Darlene Reuter, Krista Singleton, Ashley Martin, Jamie Dubaut, Alisha Preno, Kim Hyatt, James Papin, Dean Myers

O-093: Spiral Artery Remodeling in Relation to Preterm Birth and Adverse Neonatal Outcome in Preeclampsia and Fetal Growth Restriction
Laura Brouwers, Katja C.E. Drechsel, Steffie de Gier, Tatjana E. Vogelvang, Peter G.J. Nikkels, Arie Franx, Bas B. van Rijn, Floris Groenendaal

O-094: The Influence of Race on Neonatal Complications after Late Preterm Birth
Cynthia Gyamfi-Bannerman, Amy L. Turitz, Alexander M. Friedman

Developmental Programming II
Moderators:
Stephane L. Bourque, PhD
Maria B. Rabaglino, DVM MSc PhD
Room 252B - Palais des Congrès

O-095: Sexually-Dimorphic Effects of Maternal Obesity on Microglial Antigen Density in the Embryonic Hippocampus: Implications for Offspring Hippocampal Learning
Andrea G. Edlow, Ruthy M. Glass, Staci D. Bilbo

O-096: The Association between Caesarean-Section and Childhood Cognitive Ability in the UK Millennium Cohort Study
Michael T. Hanrahan, Louise Gibson, Fergus McCarthy, Ali Khashan

O-097: Maternal Obesity (MO) in an Ovine Model Results in Disruption of Offspring (F1) Mitochondrial Respirasomes
Inês Cardoso, Teresa Cunha-Oliveira, Susana P. Pereira, Christopher Pankey, Qiurong Wang, McKenna M. Considine, Stephen Ford, Peter W. Nathanielsz, Paulo J. Oliveira

O-098: Growth Trajectories of the Human Brain in Complicated Pregnancies and the Association with Neurodevelopmental Outcome at 2 Years of Age
Mila S. Welling, Sofie C. Husen, Hilmar H. Bijma, Attie T.J.I. Go, Irene A.L. Groenenberg, Sten P. Willemsen, Régine P.M. Steegers-Theunissen.

O-099: Activation of β-Catenin Responsive Genes through Epigenetic Reprogramming in Myometrial Stem Cells Developmentally Exposed to Endocrine Disrupting Chemicals
Qiwei Yang, Mohamed Ali, Lindsey S Treviño, Cheryl L Walker, Ayman Al-Hendy

O-100: The Effect of Estriol on the Brain Function and Behavior in Offspring
Yuping Zhou, Xiao-Bing Gao

Epidemiology and Global Health
Moderators:
Gaurang S. Daftary, MD
Alireza A. Shamshirsaz, MD
Room Maillot - Palais des Congrès

O-101: Neighborhood Socioeconomic Deprivation and Decidual Vasculopathy.
Vanessa Assibey-Mensah, Dara Mendez,Kelly Carey, William Parks, Janet Catov

O-102: Association between Hypertensive Disorders of Pregnancy and Autism Spectrum Disorder: A Population-Based Study
Gillian M. Maher, Gerard W. O'Keeffe, Christina Dalman,Patricia M. Kearney, Fergus P. McCarthy, Louise C. Kenny, Ali S. Khashan

O-103: Tizoxanide Exerts Anti-Viral Effects by Inhibiting ZIKA Virus Replication in Infected-Human Endometrial Stromal Cells (HESCs), First Trimester (FTDCs) and Term Decidual Cells (TDCs): Implications in Preventing ZIKV Infection
Ozlem Guzeloglu-Kayisli, Xiaofang Guo, Nihan Semerci, Asli Ozmen, Kellie Larsen, Aayat Sabah, Frederick Schatz, Umit A. Kayisli, Charles J Lockwood

O-104: Understanding the Epidemic of Drug Use in Pregnancy and Postpartum: A Study from the United States National Emergency Department Database
Emma Giuliani, Shani Chibber, Regina Baker, Maya Millette, Luke Burns, Courtney Townsel, Erica Marsh

O-105: Racial and Ethnic Disparities in Cesarean Morbidity
Adina Kern-Goldberger, Whitney Booker, Alexander Friedman, Cynthia Gyamfi-Bannerman

O-106: Time Trends in Socioeconomic Status Related Disparities in Perinatal Outcomes in the Netherlands 2000-2016
Loes C.M. Bertens, Eric A.P. Steegers, Jasper V. Been

Placenta II
Moderators:
Shiao-Yng Chan, MD, PhD, FRCOG
Owen R. Vaughan, PhD
Ampi Bleu - Palais des Congrès

O-107: Hand1 Impairs Angiogenesis in the Placenta
Jennifer A. Courtney, Helen N. Jones

O-108: Chloroquine Enhances Targeted Nanoparticle Delivery of Epidermal Growth Factor to Human Placental Explants
Lewis Renshall, Annie Evans, Frances Beards, Susan Greenwood, Lynda Harris

O-109: Derivation of Macaque Trophoblast Stem Cells: A Platform for Interrogating Gene Function in Primate Placentation
Jenna Schmidt, Michael Meyer, Gregory Wiepz, Brittany Dusek, Thaddeus Golos

O-110: Molecular Characterization of Trophoblast Stem Cells Established from Complete Hydatidiform Mole
Sota Takahashi

O-111: Impairment of Placental Development and Fetal Growth Due to Inflammation during Early Pregnancy: Role of Uterine Natural Killer Cells
Kelly J. Baines, Amanda M. Rampersaud, Dendra M. Hillier, Stephen J. Renaud

O-112: Placental Extracellular Vesicle Signalling in Cre-loxP Mouse Model
Jessica F. Hebert, Matthew Bucher, Alina Maloyan, Terry K. Morgan

Reproductive Biology II
Moderators:
Sarah Anne Robertson, PhD
Yalda Afshar, MD, PhD
Room 241 - Palais des Congrès

O-113: A Three-Dimensional Complex Organoid Co-Culture System to Study Human Embryo Implantation In Vitro
Thomas M. Rawlings, Norikazu Ueki, Komal Makwana, Paul J. Brighton, Jan J. Brosens

O-114: A Multi-Omics Approach for Assessing the Molecular Underpinnings of Early Pregnancy Loss
Sangeetha Mahadevan, Ying-Wan Wooi, Li Su, Nigel Lee, Yi-Hsien Chen, Hamssika Chandrashekaran, Sung Yun Jung,1 Zhandong Liu, Ignatia Van den Veyver

O-115: Multi-Methodological Approach Defines Sub-Populations of Epithelial Cells in Human Endometrium
Alison Maclean, Jaipal Bhullar, Satomi Miwa, Thomas von Glinicki, Camilo De Lelis Medeiros-de-Morais, Francis L. Martin, Anthony J. Valentijn, Olga Vasieva, Nicola Tempest, Jo Drury, Dharani Hapangama

O-116: Characterization of Bone Marrow-Derived Cells Contribution to Endometrial Remodeling in the Postpartum Period
Reshef Tal, Shafiq Shaikh, Harvey J. Kliman, Ramana Mamillapalli, Hugh S. Taylor

O-117: Interleukin-1β Inhibits Steroid Receptors and Other Biomarkers of Human Endometrial Stromal Cell Differentiation: Implications for Inflammation-Associated Infertility
Jie Yu, Sarah L Berga, Wei Zou, Robert N. Taylor

O-118: Uterine Fluid (UF)-Derived Extracellular Vesicles (EVs) as a Potential Noninvasive Proxy of Endometrial Transcriptomic Status
Elisa Giacomini, Giulia Maria Scotti, Dejan Lazarevic, Fabio Simeoni, Ivan Molineris, Sofia Makieva, Enrico Papaleo, Giovanni Tonon, Paola Viganò

Reproductive Endocrinology II
Moderators:
Genevieve S. Neal-Perry, MD, PhD
Amanda N. Kallen, MD
Room 242AB - Palais des Congrès

O-119: Increased Levels of Thromboinflammatory Factors in Pregnant Women with PCOS at Term Detected by Quantitative Label-Free Plasma Proteomics
Riikka K. Arffman, Mayank Saraswat, Masuma Khatun, Rahul Agarwal, Tiialotta Tohmola, Susanne Lager, Inger Sundström-Poromaa, Sakari Joenväärä, Risto Renkonen, Terhi T. Piltonen.

O-120: Oocyte Retrieval and Maturation Rate from Very Young Pre-Menarche Girls
Gilad Karavani, Natali Schachter-Safrai, Talya Daniel - Mordechai, Ariel Revel, Tal Imbar

O-121: Anti-Inflammatory Therapy Suppresses Nutrient-Stimulated Circulating Tumor Necrosis Factor-A Levels and Suppressor of Cytokine-3 Expression in Lean Women with Polycystic Ovary Syndrome (PCOS)
Frank González, Kieren J. Mather, Robert V. Considine, Anthony J. Acton

O-122: Relationship between Luteal Serum and Urinary Hormones in Women Traversing Menopause: Study of Women's Health Across the Nation Daily Hormone Study (SWAN DHS)
Nanette Santoro, Samar El Khoudary, Gail L. Greendale, Dan McConnell, Alexis Nasr, Genevieve Neal-Perry, Jelena Pavlovic, Carol Derby, Ellen B. Gold

O-123: Insulin Increases Kisspeptin Expression in Hypothalamus and Induces Early Puberty in Lean, Hyperinsulinemic Murine Model
Farrah L. Saleh, Aditi A. Joshi, Clare A. Flannery

O-124: Ibuprofen Inhibits Expression of Key Genes Involved in Androgen Production by Rat Theca Interstitial Cells and Abrogates Effects of IL-1ß
Chelsea W. Fox, Lingzhi Zhang, Antoni Duleba

Fetus II
Moderators:
Mikko Hallman, MD, PhD
Eileen I. Chang, PhD
Room 251 - Palais des Congrès

O-125: Conditional Double Deletion of Dnmt3a and Dnmt3b in the Second Heart Field Progenitors Ameliorates Maternal Diabetes-Induced Congenital Heart Defects
Penghua Yang, Peixin Yang

O-126: Placental Mechanistic Target of Rapamycin (mTOR) Controls Fetal Pancreatic Beta (β) Cell Development and Function: A Potential Therapeutic Target in Intrauterine Growth Restriction (IUGR)
Fredrick J. Rosario, Sydney L. Coates, Colleen G. Julian, Lorna G. Moore, Theresa L. Powell, Thomas Jansson

O-127: PreImplantation Factor Dictates Oligodendrocyte Differentiation by Modulating NCOR2 Methylation in H19 Dependent Manner
Marialuigia Spinelli, Daniel Surbek, Andreina Schoeberlein, Irene Keller, Angelique Bordey, Eytan Barnea, Michael Paidas, Martin Mueller

O-063: Greater STAT3 Phosphorylation and Enhanced Mitochondrial Respiration in the Left Ventricle of Growth Restricted Ovine Fetuses
A.T. Antolic, A.L. Pendleton, A.C. Kelly, M.J. Anderson, M.A. Davis, C.A. Bidwell, L.E. Camacho, S.W. Limesand

O-129: Nanoparticle-Encapsulated Antioxidant Delivery Reduces Placental Nitrosative Stress in a Sex-Specific Manner in a Rat Model of Fetal Hypoxia
E. Ganguly, M.M. Aljunaidy, J.S. Morton, R. Kirschenman, C.L. Cooke, C.P. Case, S.T. Davidge

O-130: Novel Gasotransmitter Protection against Fetal Origins of Vascular Disease: The Role of Hydrogen Sulphide
B J. Krause, T. A. Garrud, S. G. Ford, Y. Niu, D. A. Giussani

Gynecologic Oncology
Moderators:
Dineo Khabele, MD
Rebecca Phaeton
Room 253 - Palais des Congrès

O-131: Targeting Sonic Hedgehog Signaling in Human Leiomyosarcoma Cells by SMO and GLI1 Inhibition
Natalia Garcia, Katia Carvalho, Ayman Al-Hendy, Qiwei Yang

O-132: Progesterone-Resistant Endometrial Cancers in Mice with Deletion of Pten and Dicer
Shannon M. Hawkins, Xiyin Wang, Robert Emerson, Chi Zhang, Russell Broaddus, Francesco DeMayo, John Lydon

O-133: Circulating Exosomal miRNAs from Women with Ovarian Cancer for Early Detection and Real-Time Monitoring of Disease Progression
Shayna Sharma, Andrew Lai, Dominic Guanzon, Terry Morgan, Lewis C Perrin, John D Hooper, Carlos Salomon

O-134: Estriol (E3) Exposure during Pregnancy and Altered Mammary Gland Cancer - Associated Gene Expression
Ramanaiah Mamillapalli, Jehanzeb Kayani, Joshua Huttler, Hugh S. Taylor

O-135: The Role of Human Endothelial Colony Forming Cells in the Vascular Supply and Expansion of SKOV3-cells in a Murine Artificial Organ Xenograft Model
Eleonor Hill, English William, Tidy John, D.O.C. Anumba, Peter Sipos.

O-136: Targeted Blockade of STAT3 Signaling Inhibits Proliferation and Collagen Production, and Induces Apoptosis of Uterine Leiomyoma and Leiomyosarcoma Cells
Minnie Malik, Joy Britten, William Catherino

Parturition III
Moderators:
Rachel M. Tribe, PhD
Joy V. Vink
Room 252B - Palais des Congrès

O-137: Loss of TPRV4 Attenuates NFκB Activation and Inflammation Thereby Decreasing Murine Susceptibility to LPS-Induced Preterm Labor
Judith A. Ingles, Zahidee Rodriguez, Lihua Ying, David N. Cornfield, Cristina M. Alvira

O-138: Maternal Restrained Stress Induces Preterm Birth (PTB) is Associated with Glucocorticoid Independent Functional Progesterone (P4) Withdrawal
Kellie Larsen, Ozlem Guzeloglu-Kayisli, Asli Ozmen, Nihan Semerci, Xiaofang Guo, Frederick Schatz, Charles Lockwood, Umit Kayisli

O-139: Three-Dimensional Noninvasive Electromyometrial Imaging (EMMI) of Uterine Contractions Effects of Geometric Alterations
Hui Wang, Wenjie Wu, Michael Talcott, Robert Mckinstry, Pamela K. Woodard, George A. Macones, Alan L. Schwartz, Phillip Cuculich, Alison G. Cahill, Yong Wang

O-140: Non-Competitive Inhibitor of the IL-1 Receptor Prevents Leukocyte Infiltration of the Maternal Uterus and the Fetal Brain and Lung during IL-1β-Induced Preterm Birth in Mice
Han Lee, Meghan Onushko, Xin Fang, Sylvain Chemtob, David M Olson

O-141: Wavelength Specific Photo-Mediated Relaxation of Pre-Contracted Human Uterine Smooth Muscle Occurs via Endogenous Opsin 3 Receptor Activation
George Gallos, Shunsuke Hyuga, Peter Yim, Ronald Wapner, Joy Vink

O-142: The Polyphenols Punicalagin and Gallic Acid May Be Novel Therapeutics for Preterm Birth
Caitlyn Nguyen-Ngo, Ratana Lim, Martha Lappas

Placenta III
Moderators:
Cathy Vaillancourt, PhD
Nihar R. Nayak, DVM, PhD
Room 242AB - Palais des Congrès

O-143: Decreased Incorporation of Free Fatty Acids and De Novo Synthesis in Primary Human Trophoblast Cells Isolated from Obese Gestational Diabetic Women
Marisol Castillo-Castrejon, Veronique Ferchaud-Roucher, Thomas Jansson, Theresa L. Powell

O-144: Reduced AMPK Signaling Impairs Placental Mitophagy in Women with Gestational Diabetes Mellitus
Heqin Yang, Yun Chen, Chandra Yallampalli, Haijun Gao

O-145: Spermine Synthase (SMS), a Placenta Specific X Chromosome Inactivation (XCI) Escapee, Mediates Sex-Differences in Placental Mitochondrial Function
Irving Aye, Sung Gong, Stephen Charnock-Jones, Gordon Smith

O-146: Iron Transport to the Fetus is Controlled by a ‘Selfish’ Placenta
Veena Sangkhae, Allison L. Fisher, Tomas Ganz, Elizabeta Nemeth

O-147: Umbilical Cord Stem Cell-Derived Exosomes as a Treatment in Hypoxic-Ischemic Brain Injury
Gierin Thomi, Marianne S. Joerger-Messerli, Valérie Haesler, Daniel V. Surbek, Andreina Schoeberlein

O-148: Placental Perfusion and Fetal Blood Oxygen Saturation Measured with MRI in Normal Pregnancy and Fetal Growth Restriction
Rosalind Aughwane, Magdalena Sokolska, Dimitra Flouri, Rebecca Spencer, Katarzyna Maksym, Nada Mufti, Alan Bainbridge, David Atkinson, Giles Kendall, Jan Deprest, Tom Vercauteren, Sebastien Ourselin, Andrew Melbourne, Anna L. David

Preeclampsia II
Moderators:
Claire T. Roberts, PhD
Tamara Saez, PhD
Room Maillot - Palais des Congrès

O-149: Dysfunctional Mitochondrial Fatty Acid Oxidation Precedes the Development of Early-Onset Preeclampsia
Kathryn J. Gray, David E. Cantonwine, Thomas F. McElrath, Richa Saxena

O-150: Cell-Free DNA Methylation Profiles in Preeclampsia Highlight Multi-Organ Involvement Identifying Potential Targets for Future Sequelae
Irene Corachan, Tamara Garido-Gomez, Davide Bau, Roser Navarro, David Blesa, Alfredo Perales, Antonio Diez-Juan, Carlos Simon

O-151: Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Ameliorate Preeclampsia-Associated Fetal Loss/Growth Restriction and Modulate Intrauterine Macrophage Populations
Elizabeth Taglauer, Gareth Willis, Angeles Fernandez-Gonzalez, Reis Monica, Xianlan Liu, Alex Mitsialis, Stella Kourembanas

O-152: Effects of Syncytiotrophoblast Extracellular Vesicles on Angiotensin II-Induced Vasoconstriction in Uterine Arteries from Lectin-Like Oxidized LDL Receptor-1 Overexpressing Mice
Floor Spaans, Jude S. Morton, Raven Kirschenman, Tatsuya Sawamura, Dionne S. Tannetta, Ian L. Sargent, Sandra T. Davidge

O-153: Preeclampsia is Associated with Impaired Lymphangiogenic and Immune Cell Trafficking Function of Decidual Lymphatic Endothelial Cells
Ja-Young Kwon, Hanoll Pi, Yun Ji Jung, Yejin Park, Ha-Yan Kwon, Yong-Sun Maeng

O-154: Regulatory T Cell Deficiency Increases Resistance to Uteroplacental Blood Flow, Leading to Fetal Growth Restriction
Alison S. Care, Stephane L. Bourque, Jude S. Morton, Emma P. Hjartarson, Jacqueline Humphries, Sandra T. Davidge, Sarah A. Robertson

Reproductive Biology III
Moderators:
Kutluk H. Oktay, MD, PhD
Nathalie di Clemente, PhD
Room Maillot - Palais des Congrès

O-155: Fate Map of Decidual Innate Lymphoid Cells Reveals Gestational Plasticity
Aleksandar K. Stanic, Yan Li, Jessica Vazquez

O-156: Estrogen Induces Ciliogenesis in 3D Organoid Cultures of Human Endometrial Glands
Sandra Haider, Magdalena Gamperl, Leila Saleh, Jürgen Pollheimer, Paulina Latos, Martin Knöfler

O-157: Reconstitution of Oogenesis in Mice using Bone Marrow-Derived Stem Cells Aggregated with Fetal Ovarian Somatic Cells
Jessica J. Martin, Paulo H.A. Campos, Dori C. Woods, Jonathan L. Tilly

S-229: Notch Activation Promotes Migration of Human Trophoblast Cells
Barry E. Perlman, Salma Begum, Tracy Wu, Sara S. Morelli, Carrie J. Shawber, Nataki C. Douglas

MOVED TO POSTER SESSION II
O-158: Novel Decidual Immune Cell Subsets are Revealed through Single Cell RNA-Seq
Adam Jelinski, Moriya Gamliel, Shuang-Yin Wang, Naama Elefant, Debra Goldman-Wohl, Ronit Gilad, Yishai Sompolinsky, Ofer Mandelboim, Ido Amit, Simcha Yagel

O-159: Isolation of Putative Human Oogonial Stem Cells by a NANOG SmartFlare RNA Detection Probe and Fluorescence-Activated Cell Sorting (FACS)
Yvonne L. Clarkson, Christos Lamprianidis, Marie McLaughlin, Martin Waterfall, Richard A. Anderson, Evelyn E. Telfer

O-160: Regulatory T Cells are a Key Agent of Progesterone Effects in Early Pregnancy
Ella S. Green, Lachlan M. Moldenhauer, Shaun M. McColl, Sarah A. Robertson