President's Distinguished Lecturer II

PRESIDENT'S DISTINGUISHED LECTURER II

Chuan He, PhD
John T. Wilson Distinguished Service Professor
University of Chicago, Department of Chemistry

Gene expression regulation by RNA methylation

Friday, March 28, 2025
8:10 a.m. - 9:00 a.m.

 

---

Over 150 types of post-transcriptional RNA modifications have been identified in all kingdoms of life. We have discovered RNA demethylation and shown that reversible RNA modification could impact a wide range of biological processes. We have also characterized proteins that selectively recognize m6A-modified mRNA and affect the translation status and lifetime of the target RNA. I will introduce both posttranscritional and transcriptional regulation through RNA methylation. I will focus on presenting our recent discoveries on chromatin state regulation by chromatin-associated regulatory RNA (carRNA) methylation.

 

https://pubmed.ncbi.nlm.nih.gov/30262497/

https://pubmed.ncbi.nlm.nih.gov/31949099/

https://pubmed.ncbi.nlm.nih.gov/35511947/

 

---